Donders Institute for Brain Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
Hum Brain Mapp. 2022 Sep;43(13):3923-3943. doi: 10.1002/hbm.25893. Epub 2022 Apr 30.
After experiences are encoded, post-encoding reactivations during sleep have been proposed to mediate long-term memory consolidation. Spindle-slow oscillation coupling during NREM sleep is a candidate mechanism through which a hippocampal-cortical dialogue may strengthen a newly formed memory engram. Here, we investigated the role of fast spindle- and slow spindle-slow oscillation coupling in the consolidation of spatial memory in humans with a virtual watermaze task involving allocentric and egocentric learning strategies. Furthermore, we analyzed how resting-state functional connectivity evolved across learning, consolidation, and retrieval of this task using a data-driven approach. Our results show task-related connectivity changes in the executive control network, the default mode network, and the hippocampal network at post-task rest. The hippocampal network could further be divided into two subnetworks of which only one showed modulation by sleep. Decreased functional connectivity in this subnetwork was associated with higher spindle-slow oscillation coupling power, which was also related to better memory performance at test. Overall, this study contributes to a more holistic understanding of the functional resting-state networks and the mechanisms during sleep associated to spatial memory consolidation.
在经历被编码后，睡眠期间的后编码再激活被提出可以介导长期记忆的巩固。非快速眼动睡眠期间的纺锤波-慢波振荡耦合是一种候选机制，通过这种机制，海马-皮质对话可能会增强新形成的记忆印痕。在这里，我们通过一个涉及到离心和自我中心学习策略的虚拟水迷宫任务，研究了快速纺锤波和慢纺锤波-慢波振荡耦合在人类空间记忆巩固中的作用。此外，我们使用数据驱动的方法分析了在完成任务、巩固和检索期间，静息态功能连接是如何演变的。我们的结果表明，在任务后静息时，执行控制网络、默认模式网络和海马网络中存在与任务相关的连接变化。海马网络可以进一步分为两个子网，其中只有一个子网受到睡眠的调节。该子网的功能连接减少与更高的纺锤波-慢波振荡耦合功率相关，这也与测试时更好的记忆表现相关。总的来说，这项研究有助于更全面地了解与空间记忆巩固相关的功能静息态网络和睡眠期间的机制。
