Kipnis T L, Tambourgi D V, Sucupira M, Dias-da-Silva W
Braz J Med Biol Res. 1986;19(2):271-8.
When T. cruzi trypomastigote forms are held at 45 degrees C for 10 min in saline they become susceptible to lysis by the alternative complement pathway. As the result of heating trypomastigotes, but not epimastigotes, substances are released into the fluid phase which inhibit EAC1,4,2,3 by inducing decay. The inhibition was most pronounced at the level of the decay of the C14b2a complex. C3 convertase of the classical pathway was also inhibited by live trypomastigote forms. These data suggest that the trypomastigote but not epimastigote forms of T. cruzi have cell surface modulators of C3 convertase that permit them to evade the lytic action of complement.
当克氏锥虫的锥鞭毛体形式在盐水中于45摄氏度保持10分钟时，它们会变得易被替代补体途径溶解。加热锥鞭毛体而非无鞭毛体的结果是，有物质释放到液相中，通过诱导衰变来抑制EAC1,4,2,3。这种抑制在C14b2a复合物衰变水平最为明显。经典途径的C3转化酶也受到活的锥鞭毛体形式的抑制。这些数据表明，克氏锥虫的锥鞭毛体形式而非无鞭毛体形式具有C3转化酶的细胞表面调节剂，这使它们能够逃避补体的溶解作用。
