State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, P. R. China.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, 19 (A) Yuquan Road, Beijing, 100049, P. R. China.
Adv Healthc Mater. 2022 Jul;11(14):e2200287. doi: 10.1002/adhm.202200287. Epub 2022 May 7.
The construction of hierarchical porous structure in biomaterials is of great significance for improving nutrient transport and biological performance. However, it is still challenging to design porous bone substitutes with high strength and biological properties, which limits their clinical applications in load-bearing bone regeneration. Herein, based on hierarchical porous structure of renewable bamboo, the mineralized calcium phosphate/bamboo composite scaffolds with high strength and excellent transport performance are successfully prepared in combination of biotemplated approach and biomimetic mineralization. The mineralized biomaterials have simultaneously achieved high mechanical strength and low modulus, similar to those of cortical bone. Furthermore, the mineralized biomaterials exhibit good liquid transport capacity and can transport cells along anti-gravity direction. Based on density functional theory (DFT) calculations, the mineralized calcium phosphate reveals the optimal H O adsorption energy (-0.651 eV) and low diffusion energy barrier (0.743 eV), which is conducive to enhance hydrophilicity and liquid transport performance. Moreover, owing to the synergistic effect of the porous structure of biotemplate and bioactive mineralized components, the mineralized biomaterials possess enhanced bone integration and osteoconduction properties. The present study shed light on deeper understanding of mineralized biosourced materials, offering a strategy of combining green chemistry with tissue engineering to prepare eco-friendly biomaterials.
生物材料中分级多孔结构的构建对于改善营养物质传输和生物性能具有重要意义。然而，设计具有高强度和生物性能的多孔骨替代物仍然具有挑战性，这限制了它们在承重骨再生中的临床应用。在此，基于可再生竹子的分级多孔结构，通过生物模板法和仿生矿化相结合，成功制备了具有高强度和优异传输性能的矿化磷酸钙/竹复合材料支架。矿化生物材料同时实现了高机械强度和低模量，类似于皮质骨。此外，矿化生物材料表现出良好的液体传输能力，可以沿反重力方向运输细胞。基于密度泛函理论（DFT）计算，矿化磷酸钙具有最佳的 H2O 吸附能（-0.651 eV）和低扩散能垒（0.743 eV），有利于增强亲水性和液体传输性能。此外，由于生物模板的多孔结构和生物活性矿化成分的协同作用，矿化生物材料具有增强的骨整合和骨传导性能。本研究为深入了解矿化生物源材料提供了启示，为制备环保生物材料提供了一种将绿色化学与组织工程相结合的策略。
