Department of Otorhinolaryngology and Head & Neck Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Department of Medical Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
Eur Arch Otorhinolaryngol. 2022 Jul;279(7):3519-3523. doi: 10.1007/s00405-022-07413-8. Epub 2022 Apr 30.
The aim of this study was to investigate the possible role of raftlin (RFTN) in chronic rhinosinusitis with nasal polyps (CRSwNP). There is no study in the literature investigating the role of RFTN in the pathogenesis of CRSwNP.
The present study was designed as a case-control study and conducted between 25.09.2020 and 01.01.2022. CRSwNP and control groups were formed in the study. Serum and tissue samples were taken from each patient in the study and their RFTN levels were measured. While nasal polyps were used for tissue samples in the CRSwNP group, middle meatus mucosa obtained during concha bullosa surgery was used in the control group.
The control group included 31 patients (8 female, 23 male) and the CRSwNP group included 49 patients (14 female, 35 male). The mean age of the control group was 40.42 ± 9.99 years, while the mean age of the CRSwNP group was 43.47 ± 10.19 years. When the groups are compared in terms of gender and age, there were no statistically significant differences (p = 0.78, p = 0.19, respectively). The serum RFTN levels in the control and CRSwNP groups were 7.85 ± 10.87 ng/ml, and 7.02 ± 8.59 ng/ml, respectively (p = 0.45). The tissue RFTN levels in the control group and CRSwNP group were 87.15 ± 69.91 ng/ml, and 66.50 ± 17.10 ng/ml, respectively (p = 0.04, statistically significant).
RFTN deficiency in nasal polyp tissue may be one of the reasons for the development of CRSwNP. Further studies are needed to elucidate the role of RFTN in CRSwNP.
本研究旨在探讨 Raftlin（RFTN）在慢性鼻鼻窦炎伴鼻息肉（CRSwNP）中的可能作用。目前尚无研究探讨 RFTN 在 CRSwNP 发病机制中的作用。
本研究设计为病例对照研究，于 2020 年 9 月 25 日至 2022 年 1 月 1 日进行。研究中形成了 CRSwNP 组和对照组。从每位患者中采集血清和组织样本，并测量其 RFTN 水平。CRSwNP 组使用鼻息肉组织样本，对照组使用泡状鼻甲手术中获得的中鼻甲黏膜。
对照组包括 31 例患者（女性 14 例，男性 17 例），CRSwNP 组包括 49 例患者（女性 14 例，男性 35 例）。对照组的平均年龄为 40.42±9.99 岁，CRSwNP 组的平均年龄为 43.47±10.19 岁。两组在性别和年龄方面进行比较，无统计学差异（p=0.78，p=0.19）。对照组和 CRSwNP 组的血清 RFTN 水平分别为 7.85±10.87ng/ml 和 7.02±8.59ng/ml（p=0.45）。对照组和 CRSwNP 组的组织 RFTN 水平分别为 87.15±69.91ng/ml 和 66.50±17.10ng/ml（p=0.04，具有统计学意义）。
鼻息肉组织中 RFTN 缺乏可能是 CRSwNP 发展的原因之一。需要进一步研究阐明 RFTN 在 CRSwNP 中的作用。
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