PhD Program in Medical Sciences, Universidad de La Frontera, Temuco, Chile.
Faculty of Medicine, Universidad Católica del Maule, Talca, Chile.
J Gastrointest Cancer. 2023 Jun;54(2):513-519. doi: 10.1007/s12029-022-00827-x. Epub 2022 Apr 30.
Worldwide, gastric cancer (GC) is the 5 cancer with the highest incidence and the 4 in mortality. To reduce it, one strategy is to diagnose preneoplastic lesions (PNL): atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia (DYS); to form risk groups on which to focus surveillance efforts as are first-degree relatives (FDR). The aim of this study was to determine prevalence of gastric PNL in FDR of patients with GC, and to study association with sex, age, and Helicobacter pylorii (Hp) infection.
Cross-sectional study. One hundred and ten FDR, aged between 50 and 65 years, 54.5 female, obtained through convenience sampling, were studied. Biodemographic data survey and upper gastrointestinal endoscopy with histological study were applied according to Sidney protocol, and focal lesions found. Diagnosis of these lesions and condition of mucosa was carried out by applying OLGA and OLGIM systems. Descriptive statistics, estimation of prevalence, odds ratio (OR), and 95% confidence intervals (95CI) were calculated.
Median age of study group was 56.5 years. Prevalence of PNL, AG, IM, and DYS were 86.4%, 82.7%, 54.5%, and 12.7% respectively. Advanced stages of OLGA and OLGIM were verified in 18.0% and 16.3% respectively. No association with sex, age, and Hp infection were found ([OR 3.10; 95CI 1.0; 9.64]; [OR 0.74; 95CI 0.26; 2.14]; [OR 0.58; 95CI 0.12; 2.77]) respectively.
FDR of patients with GC have a high prevalence of PNL, which makes them a risk group in which endoscopic surveillance should be applied.
在全球范围内，胃癌（GC）是发病率第 5 高和死亡率第 4 高的癌症。为了降低发病率，一种策略是诊断癌前病变（PNL）：萎缩性胃炎（AG）、肠上皮化生（IM）和发育不良（DYS）；根据一级亲属（FDR）形成关注监测的风险群体。本研究旨在确定 GC 患者 FDR 中胃 PNL 的患病率，并研究其与性别、年龄和幽门螺杆菌（Hp）感染的相关性。
横断面研究。通过方便抽样，研究了 110 名年龄在 50 至 65 岁之间的 FDR，其中 54.5%为女性。应用悉尼协议进行生物人口统计学数据调查和上消化道内窥镜检查及组织学研究，并发现局灶性病变。应用 OLGA 和 OLGIM 系统对这些病变和黏膜状况进行诊断。计算描述性统计数据、患病率估计、比值比（OR）和 95%置信区间（95CI）。
研究组的中位年龄为 56.5 岁。PNL、AG、IM 和 DYS 的患病率分别为 86.4%、82.7%、54.5%和 12.7%。OLGA 和 OLGIM 的高级别分期分别为 18.0%和 16.3%。未发现性别、年龄和 Hp 感染与 PNL 相关（OR 3.10；95CI 1.0；9.64）；（OR 0.74；95CI 0.26；2.14）；（OR 0.58；95CI 0.12；2.77）。
GC 患者的 FDR 患有 PNL 的高患病率，这使他们成为需要应用内镜监测的风险群体。
