Department of Neuroscience, The Ohio State University, Columbus, OH, USA; Medical Scientist Training Program, The Ohio State University, Columbus, OH, USA.
Department of Neuroscience, The Ohio State University, Columbus, OH, USA; Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH, USA; The Belford Center for Spinal Cord Injury, The Ohio State University, Columbus, OH, USA.
Curr Opin Pharmacol. 2022 Jun;64:102230. doi: 10.1016/j.coph.2022.102230. Epub 2022 Apr 27.
Infections impair neurological outcome and increase mortality after spinal cord injury (SCI). Emerging data show that pathogens more easily infect individuals with SCI because SCI disrupts neural and humoral control of immune cells, culminating with the development of "SCI-induced immune deficiency syndrome" (SCI-IDS). Here, we review data that implicate autonomic dysfunction and impaired neuroendocrine signaling as key determinants of SCI-IDS. Although it is widely appreciated that mature leukocyte dysfunction is a canonical feature of SCI-IDS, new data indicate that SCI impairs the development and mobilization of immune cell precursors in bone marrow. Thus, this review will also explore how the post-injury acquisition of a "bone marrow failure syndrome" may be the earliest manifestation of SCI-IDS.
感染会损害脊髓损伤 (SCI) 后的神经功能预后并增加死亡率。新出现的数据表明，病原体更容易感染 SCI 患者，因为 SCI 会破坏免疫细胞的神经和体液控制，最终导致“SCI 诱导的免疫缺陷综合征” (SCI-IDS) 的发生。在这里，我们回顾了表明自主神经功能障碍和神经内分泌信号受损是 SCI-IDS 的关键决定因素的数据。尽管人们普遍认为成熟白细胞功能障碍是 SCI-IDS 的一个典型特征，但新的数据表明，SCI 会损害骨髓中免疫细胞前体的发育和动员。因此，本综述还将探讨受伤后获得的“骨髓衰竭综合征”如何可能是 SCI-IDS 的最早表现。
