Zaccaria A, Rosti G, Testoni N, Alimena G, Arcese W, Bandini G, Boogaerts M, Carbonell F, Ferrant A, Filippetti A
Cancer Genet Cytogenet. 1987 May;26(1):5-13. doi: 10.1016/0165-4608(87)90128-2.
The karyotypes of 74 patients with Ph-positive chronic myeloid leukemia submitted to bone marrow transplantation collected from nine institutions were studied serially before and after transplantation. In 13 cases sporadic Ph-positive metaphases were detected without signs of relapsing disease at various intervals after transplantation. These data indicate that the leukemic clone may not be completely suppressed by the conditioning treatment and that other biological mechanisms may be involved in destroying this clone or controlling its expansion.
对来自9个机构的74例接受骨髓移植的Ph阳性慢性髓性白血病患者的核型在移植前后进行了连续研究。在13例中，移植后不同时间间隔检测到散在的Ph阳性中期细胞，无疾病复发迹象。这些数据表明，白血病克隆可能未被预处理完全抑制，其他生物学机制可能参与破坏该克隆或控制其扩增。
