Andersson B S, Beran M, Pathak S, Goodacre A, Barlogie B, McCredie K B
Cancer Genet Cytogenet. 1987 Feb;24(2):335-43. doi: 10.1016/0165-4608(87)90116-6.
Blast cells from a 39-year-old man in the blastic phase of chronic myeloid leukemia, with a benign phase of 15 years duration, as well as a cell line arising from this cell population, were studied. Cellular morphology, cytochemical staining pattern, and absence of terminal deoxynucleotidyl transferase showed the blast cells to be of myeloid character. Cytogenetic studies revealed the presence of two near-haploid cell populations with +8 and +8, +15, respectively, both of them containing the translocation t(9;22) in the original tumor cell sample. The cell line derived from this patient's leukemic cell sample contained both near-haploid and hyperdiploid clones, the hyperdiploid clones being multiples of the near-haploid clone(s). All of the clones carried the t(9;22) in the form of a Philadelphia chromosome.
对一名39岁处于慢性髓性白血病急变期的男性患者的原始细胞进行了研究，该患者有15年的良性病程，同时还研究了源于该细胞群体的细胞系。细胞形态学、细胞化学染色模式以及末端脱氧核苷酸转移酶的缺失表明原始细胞具有髓系特征。细胞遗传学研究显示存在两个近单倍体细胞群体，分别为+8和+8、+15，在原始肿瘤细胞样本中两者均含有易位t(9;22)。源自该患者白血病细胞样本的细胞系包含近单倍体和超二倍体克隆，超二倍体克隆是近单倍体克隆的倍数。所有克隆均以费城染色体的形式携带t(9;22)。
