Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovičova 6, 842 15, Bratislava, Slovakia.
Environ Pollut. 2022 Aug 1;306:119346. doi: 10.1016/j.envpol.2022.119346. Epub 2022 Apr 27.
Bisphenol A (BPA), as a major component of some plastic products, is abundant environmental pollutant. Due to its ability to bind to several types of estrogen receptors, it can trigger multiple cellular responses, which can contribute to various manifestations at the organism level. The most studied effect of BPA is endocrine disruption, but recently its prooxidative potential has been confirmed. BPA ability to induce oxidative stress through increased ROS production, altered activity of antioxidant enzymes, or accumulation of oxidation products of biomacromolecules is observed in a wide range of organisms - estrogen receptor-positive and -negative. Subsequently, increased intracellular oxidation can lead to DNA damage induction, represented by oxidative damage, single- and double-strand DNA breaks. Importantly, BPA shows several mechanisms of action and can trigger adverse effects on all organisms inhabiting a wide variety of ecosystem types. Therefore, the main aim of this review is to summarize the genotoxic effects of BPA on organisms across all taxa.
双酚 A（BPA）作为某些塑料制品的主要成分，是一种丰富的环境污染物。由于其能够与多种类型的雌激素受体结合，因此可以引发多种细胞反应，从而导致生物体水平的多种表现。BPA 最受研究的作用是内分泌干扰，但最近其促氧化潜能已得到证实。BPA 通过增加 ROS 产生、改变抗氧化酶活性或生物大分子氧化产物积累来诱导氧化应激的能力，在广泛的生物体中都有观察到 - 包括雌激素受体阳性和阴性的生物体。随后，细胞内氧化增加可导致 DNA 损伤诱导，表现为氧化损伤、单链和双链 DNA 断裂。重要的是，BPA 具有多种作用机制，并可能对栖息在各种生态系统类型中的所有生物体引发不良影响。因此，本综述的主要目的是总结 BPA 对所有分类群生物体的遗传毒性作用。
