Université Toulouse 3 Paul Sabatier, CNRS, IRD, UMR5174 EDB (Laboratoire Évolution & Diversité Biologique), Toulouse, France; Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, P-2780 Oeiras, Portugal.
Université Toulouse 3 Paul Sabatier, CNRS, IRD, UMR5174 EDB (Laboratoire Évolution & Diversité Biologique), Toulouse, France.
Curr Opin Insect Sci. 2022 Aug;52:100925. doi: 10.1016/j.cois.2022.100925. Epub 2022 Apr 27.
Parasite proliferations within/on the host form the basis of the outcome of all infectious diseases. However, within-host dynamics are difficult to study in vertebrates, as it requires regularly following pathogen proliferation from the start of the infection and at the organismal level. Invertebrate models allow for this monitoring under controlled conditions using population approaches. These approaches offer the possibility to describe many parameters of the within-host dynamics, such as rate of proliferation, probability to control the infection, and average time at which the pathogen is controlled. New parameters such as the Pathogen Load Upon Death and the Set-Point Pathogen Load have emerged to characterize within-host dynamics and better understand disease outcome. While contextualizing the potential of studying within-host dynamics in insects to build fundamental knowledge, we review what we know about within-host dynamics using insect models, and what it can offer to our knowledge of infectious diseases.
寄生虫在宿主内/上的增殖是所有传染病结果的基础。然而，在脊椎动物中，很难研究宿主内的动态变化，因为这需要从感染开始并在机体水平上定期监测病原体的增殖。无脊椎动物模型可以在受控条件下使用群体方法进行这种监测。这些方法提供了描述宿主内动态变化的许多参数的可能性，例如增殖速度、控制感染的概率以及控制病原体的平均时间。新的参数，如死亡时的病原体载量和设定点病原体载量，已经出现，以描述宿主内的动态变化，并更好地了解疾病的结果。在将昆虫中研究宿主内动态变化的潜力置于背景下以建立基础知识的同时，我们回顾了使用昆虫模型了解宿主内动态变化的情况，以及它为我们对传染病的认识提供了什么。
