Department of Surgery, Yokohama City University, Yokohama, Japan;
Department of Surgery, Yokohama City University, Yokohama, Japan.
Anticancer Res. 2022 May;42(5):2763-2769. doi: 10.21873/anticanres.15755.
BACKGROUND/AIM: Postoperative complications are associated with increased recurrence in colorectal cancer (CRC). We investigated the impact of infectious complications on the recurrence of CRC and overall survival after curative surgery in a single study group.
In total, 1,668 patients who underwent radical resection for CRC in Yokohama City University, Yokohama Minami Kyosai Hospital, and Kanagawa Cancer Center between 2011 and 2019 were reviewed. Patients were classified into those with infectious complications (IC group) and those without infectious complications (Non-IC group). The risk factors for recurrence-free survival (RFS) and overall survival (OS) were analyzed.
Postoperative complications were found in 560 of the 1,668 patients (33.5%), and IC, which occurred in 312 patients (18.7%), included pneumonia, anastomotic leakage, and intraperitoneal abscess. The 5-year OS rates in the Non-IC and IC groups were 95.5% and 90.4%, respectively, while the 5-year RFS rates were 74.4% and 68.1%, respectively. The multivariate analysis demonstrated that postoperative IC were significant independent risk factors for OS and RFS.
The presence of postoperative IC after CRC resection is associated with decreased long-term survival. The surgical procedure, surgical strategy, and perioperative care should be carefully planned in order to avoid causing IC.
背景/目的：术后并发症与结直肠癌（CRC）的复发率增加有关。我们在一个单一的研究组中调查了感染性并发症对 CRC 根治性手术后复发和总生存率的影响。
总共对 2011 年至 2019 年间在横滨市立大学、横滨南癌症医院和神奈川癌症中心接受 CRC 根治性切除术的 1668 名患者进行了回顾性分析。将患者分为发生感染性并发症（IC 组）和未发生感染性并发症（非 IC 组）。分析了无复发生存（RFS）和总生存（OS）的危险因素。
在 1668 名患者中，有 560 名（33.5%）发生了术后并发症，其中 312 名（18.7%）发生了 IC，包括肺炎、吻合口漏和腹腔脓肿。非 IC 组和 IC 组的 5 年 OS 率分别为 95.5%和 90.4%，5 年 RFS 率分别为 74.4%和 68.1%。多因素分析表明，术后 IC 是 OS 和 RFS 的独立危险因素。
CRC 切除术后发生术后 IC 与长期生存降低有关。应仔细计划手术过程、手术策略和围手术期护理，以避免发生 IC。
