Department of Radiology, Alfred Health, Melbourne, Victoria, Australia.
Department of Radiology, Alfred Health, Melbourne, Victoria, Australia; Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
J Vasc Interv Radiol. 2022 May;33(5):505-509. doi: 10.1016/j.jvir.2022.02.004.
Splenic artery embolization (SAE) plays a critical role in the treatment of high-grade splenic injury not requiring emergent laparotomy. SAE preserves splenic tissue, and growing evidence demonstrates preserved short-term splenic immune function after SAE. However, long-term function is less studied. Patients who underwent SAE for blunt abdominal trauma over a 10-year period were contacted for long-term follow-up. Sixteen participants (sex: women, 10, and men, 6; age: median, 34 years, and range, 18-67 years) were followed up at a median of 7.7 years (range, 4.7-12.8 years) after embolization. Splenic lacerations were of American Association for the Surgery of Trauma grades III to V, and 14 procedures involved proximal embolization. All individuals had measurable levels of IgM memory B cells (median, 14.30 as %B cells), splenic tissue present on ultrasound (median, 122 mL), and no history of severe infection since SAE. In conclusion, this study quantitatively demonstrated that long-term immune function remains after SAE for blunt abdominal trauma based on the IgM memory B cell levels.
脾动脉栓塞术（SAE）在治疗不需要紧急剖腹手术的高级别脾损伤中起着关键作用。SAE 保留了脾脏组织，越来越多的证据表明 SAE 后短期脾脏免疫功能得到保留。然而，长期功能的研究较少。对过去 10 年中因钝性腹部创伤接受 SAE 的患者进行了联系，以进行长期随访。16 名参与者（性别：女性 10 名，男性 6 名；年龄：中位数 34 岁，范围 18-67 岁）在栓塞后中位数为 7.7 年（范围 4.7-12.8 年）进行了随访。脾裂伤为美国创伤外科学会分级 III 至 V 级，14 例涉及近端栓塞。所有个体均有可测量水平的 IgM 记忆 B 细胞（中位数为 14.30%作为 B 细胞）、超声检查显示存在脾脏组织（中位数为 122 毫升），并且自 SAE 以来无严重感染史。总之，这项研究基于 IgM 记忆 B 细胞水平定量证明，在因钝性腹部创伤进行 SAE 后，长期免疫功能仍然存在。
