非预定四倍体细胞中的灾难性DNA复制。

Catastrophic DNA replication in unscheduled tetraploid cells.

作者信息

Manic Gwenola, Galluzzi Lorenzo, Vitale Ilio

机构信息

Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy.

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA.

出版信息

Trends Genet. 2022 Aug;38(8):787-788. doi: 10.1016/j.tig.2022.04.005. Epub 2022 Apr 27.

DOI:10.1016/j.tig.2022.04.005

PMID:35490031

Abstract

Unscheduled tetraploidy is a metastable state that rapidly evolves into aneuploidy. Recent findings reported by Gemble et al. demonstrate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication factors during the first G phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and extensive karyotypic alterations.

摘要

非整倍体四倍体是一种亚稳态，会迅速演变为非整倍体。Gemble等人最近的研究结果表明，新形成的四倍体细胞在全基因组复制（WGD）后的第一个G期未能积累所需数量的DNA复制因子，最终导致随后S期的遗传不稳定和广泛的核型改变。