Department of Anesthesiology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, China.
Department of Neurosurgery, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, China.
BMC Anesthesiol. 2022 Apr 30;22(1):132. doi: 10.1186/s12871-022-01665-x.
Postoperative nausea and vomiting is common in patients receiving microvascular decompression. In the current study, we examined whether postoperative nausea and vomiting is associated with reduced intraocular pressure (IOP) after microvascular decompression, a measure that reflects intracranial pressure.
This is a prospective cohort study. Adult patients scheduled for microvascular decompression surgery for hemifacial spasm between January 2020 and August 2020 were eligible. IOP was measured immediately before anesthesia induction and 30 min after patients regained complete consciousness using non-contact tonometry. IOP reduction was defined by at least 1 mmHg decrease vs. preoperative baseline. The primary outcome was vomiting on postoperative day 1.
A total of 103 subjects were enrolled. IOP was reduced in 56 (54.4%) subjects. A significantly greater proportion of patients with IOP reduction had vomiting on postoperative day 1 (51.8% (29/56) vs. 23.4% (11/47) in those without IOP reduction; p = 0.003). In the multivariate regression analysis, vomiting on postoperative day 1 was associated with female sex [odds ratio = 7.87, 95% CI: 2.35-26.32, p = 0.001] and IOP reduction [odds ratio = 2.93, 95% CI: 1.13-7.58, p = 0.027].
In patients undergoing microvascular decompression surgery, postoperative IOP reduction is associated with postoperative vomiting.
Chinese Clinical Trial Registry: ChiCTR2000029083 . Registered 13 January 2020.
微血管减压术后常发生恶心和呕吐。在本研究中，我们检查了微血管减压术后是否与眼压（IOP）降低有关，眼压降低反映了颅内压。
这是一项前瞻性队列研究。2020 年 1 月至 2020 年 8 月期间，符合接受微血管减压术治疗面肌痉挛的成年患者均符合入选条件。在麻醉诱导前和患者完全清醒后 30 分钟使用非接触眼压计测量 IOP。IOP 降低定义为与术前基线相比至少降低 1mmHg。主要结局为术后第 1 天呕吐。
共纳入 103 例患者。56 例（54.4%）患者的 IOP 降低。与 IOP 未降低的患者相比，IOP 降低的患者术后第 1 天发生呕吐的比例显著更高（51.8%（29/56）比 23.4%（11/47）；p=0.003）。在多变量回归分析中，术后第 1 天呕吐与女性[比值比（OR）=7.87，95%可信区间（CI）：2.35-26.32，p=0.001]和 IOP 降低[OR=2.93，95%CI：1.13-7.58，p=0.027]相关。
在微血管减压手术患者中，术后 IOP 降低与术后呕吐相关。
中国临床试验注册中心：ChiCTR2000029083 。登记于 2020 年 1 月 13 日。
