Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China.
Curr Pharm Des. 2022;28(17):1412-1418. doi: 10.2174/1381612828666220501165644.
Integrins are a class of cell surface adhesion molecules composed of α subunit (ITGA) and β subunit (ITGB). They belong to heterodimer transmembrane glycoproteins. Their main function in organisms is as the receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9 among integrins. ITGA9 can improve cell migration and regulate various cellular biological functions, such as tumor cell proliferation, adhesion, invasion, and angiogenesis. However, its abnormal expression mechanism in cancer and its specific role in tumor growth and metastasis are still unknown to a great extent. This review reveals the role of ITGA9 in the complex pathogenesis of many tumors and cancers, providing a new direction for the treatment of tumors and cancers. Relevant studies were retrieved and collected through the PubMed system. After determining ITGA9 as the research object, we found a close relationship between ITGA9 and tumorigenesis by analyzing the research articles on ITGA9 in the PubMed system in the last 15 years and further determined the references mainly based on the influencing factors of the articles. Thus, the role of ITGA9 in tumor and cancer genesis, proliferation, and metastasis was reviewed and analyzed. ITGA9 is an integrin subunit, which has been proved to be abnormally expressed in many tumors. After sorting and analyzing the research data, it was found that the abnormal expression of ITGA9 in a variety of tumors, including glioblastoma, rhabdomyosarcoma, melanoma, hepatocellular carcinoma, nasopharyngeal carcinoma, multiple myeloma, non-small cell lung cancer, and prostate cancer, was closely related to the proliferation, metastasis, adhesion, and angiogenesis of tumor cells. These results suggest that ITGA9 plays an important role in the occurrence and development of tumors. The integrin subunit ITGA9 may serve as a biomarker for the diagnosis of tumors and a potential therapeutic target for anti-tumor therapies.
整合素是细胞表面黏附分子的一类，由α亚基（ITGA）和β亚基（ITGB）组成。它们属于异二聚体跨膜糖蛋白。其在生物体内的主要功能是作为细胞黏附分子（CAM）和细胞外基质（ECM）的受体。根据目前的整合素分析研究，整合素α9（ITGA9）是整合素亚基之一，而整合素中对 ITGA9 的研究较少。ITGA9 可以促进细胞迁移，并调节多种细胞生物学功能，如肿瘤细胞增殖、黏附、侵袭和血管生成。然而，其在癌症中的异常表达机制及其在肿瘤生长和转移中的具体作用在很大程度上仍不清楚。本综述揭示了 ITGA9 在多种肿瘤和癌症复杂发病机制中的作用，为肿瘤和癌症的治疗提供了新的方向。通过 PubMed 系统检索并收集了相关研究，确定以 ITGA9 为研究对象，通过分析 PubMed 系统中过去 15 年关于 ITGA9 的研究文章，发现 ITGA9 与肿瘤发生之间存在密切关系，并进一步主要基于文章的影响因素确定了参考文献。因此，综述和分析了 ITGA9 在肿瘤和癌症发生、增殖和转移中的作用。ITGA9 是整合素亚基，已被证明在许多肿瘤中异常表达。对研究数据进行排序和分析后发现，ITGA9 在多种肿瘤中的异常表达，包括神经胶质瘤、横纹肌肉瘤、黑色素瘤、肝癌、鼻咽癌、多发性骨髓瘤、非小细胞肺癌和前列腺癌等，与肿瘤细胞的增殖、转移、黏附和血管生成密切相关。这些结果表明 ITGA9 在肿瘤的发生和发展中起重要作用。整合素亚基 ITGA9 可能作为肿瘤诊断的生物标志物和抗肿瘤治疗的潜在治疗靶点。
