具有抗炎活性的天然萜类化合物：抗炎药物发现的潜在先导物。
Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery.
机构信息
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China; School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine, Engineering Laboratory of Development and Application of Traditional Chinese Medicine, Collaborative Innovation Center of Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine, Engineering Laboratory of Development and Application of Traditional Chinese Medicine, Collaborative Innovation Center of Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
出版信息
Bioorg Chem. 2022 Jul;124:105817. doi: 10.1016/j.bioorg.2022.105817. Epub 2022 Apr 25.
Natural products are mainly secondary metabolites produced by plants, microorganisms, and animals, which are still abundant in modern drug discovery. Terpenoids are the most diverse group of natural products, attracting extensive attention owing to their various biological activities. This manuscript reviewed the chemical structures, anti-inflammatory activities, and mechanisms of action of 281 terpenoid natural products reported from 2010 to the present. Their biological targets and both in vitro and in vivo screening models were also surveyed and statistically summarized. This review will provide potential anti-inflammatory lead compounds and helpful information to researchers engaged in natural products and anti-inflammatory drug discovery.
天然产物主要是植物、微生物和动物产生的次生代谢产物，在现代药物发现中仍然丰富。萜类化合物是天然产物中最多样化的一类，由于其多种生物活性而受到广泛关注。本文综述了 2010 年至今报道的 281 种萜类天然产物的化学结构、抗炎活性和作用机制。还调查和统计总结了它们的生物靶点以及体外和体内筛选模型。本综述将为从事天然产物和抗炎药物发现的研究人员提供潜在的抗炎先导化合物和有用信息。
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