School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Eur J Med Chem. 2021 Jan 1;209:112860. doi: 10.1016/j.ejmech.2020.112860. Epub 2020 Sep 28.
Meroterpenoids are partially derived from the terpenoids, distributing widely in the plants, animals and fungi. The complex structures and diverse bioactivities of meroterpenoids have attracted more attention for chemists and pharmacologists. Since the first review summarized by Geris in 2009, there are absent of systematic reviews reported about meroterpenoids from the higher and lower fungi up to now. In the past decades, myriads of meroterpenoids were discovered, and it is necessary to summarize these meroterpenoids about their unique structures and promising bioactivities. In this review, we use a new classification method based on the non-terpene precursors, and also highlight the structural features, bioactivity of natural meroterpenoids from the higher and lower fungi covering the period of September 2008 to February 2020. A total of 709 compounds were discussed and cited the 182 references. Meanwhile, we also primarily summarize their occurrence, structural diversity, biological activities, and molecular targets.
生源二萜类化合物部分来源于萜类化合物，广泛分布于植物、动物和真菌中。生源二萜类化合物的复杂结构和多样的生物活性引起了化学家及药理学家的更多关注。自 2009 年由 Geris 综述的第一篇综述以来，目前尚无系统地综述报道高等真菌和低等真菌生源二萜类化合物。在过去的几十年中，发现了大量生源二萜类化合物，有必要对其独特的结构和有前途的生物活性进行总结。在本综述中，我们使用了一种新的基于非萜类前体的分类方法，并重点介绍了 2008 年 9 月至 2020 年 2 月期间高等真菌和低等真菌来源的天然生源二萜类化合物的结构特征和生物活性。共讨论了 709 种化合物，并引用了 182 篇参考文献。同时，我们还主要总结了它们的存在、结构多样性、生物活性和分子靶标。
