Lamberte Lisa E, van Schaik Willem
Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Curr Opin Microbiol. 2022 Aug;68:102150. doi: 10.1016/j.mib.2022.102150. Epub 2022 Apr 28.
Antibiotic-resistant infections are a major threat to global public health and there is an urgent need to develop new drugs and interventions to treat and prevent infections caused by antibiotic-resistant bacteria. The human gut microbiota harbours both commensals and opportunistic pathogens which can acquire resistance to antibiotics through mutation and horizontal gene transfer. The powerful combination of modern high-throughput DNA sequencing and microbiological culture methods is providing novel insights into the mechanisms of antibiotic resistance among, up to recently poorly studied, commensal bacteria in the gut. Interventions to minimise the abundance of antibiotic-resistant commensals and opportunistic pathogens include faecal microbiota transplantation and the use of live biotherapeutics, but the efficacy of these treatments remains elusive.
抗生素耐药性感染是对全球公共卫生的重大威胁，迫切需要开发新的药物和干预措施来治疗和预防由耐药细菌引起的感染。人类肠道微生物群既包含共生菌，也包含机会致病菌，它们可通过突变和水平基因转移获得对抗生素的耐药性。现代高通量DNA测序和微生物培养方法的强大组合，正在为人们提供新的见解，以了解肠道中此前研究较少的共生菌的抗生素耐药机制。旨在尽量减少耐药共生菌和机会致病菌数量的干预措施包括粪便微生物群移植和使用活体生物疗法，但这些治疗方法的疗效仍不明确。
