Cardiovascular Research Center, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an 710061, China.
East China Normal University Health Science Center, Shanghai 200241, China.
J Mol Cell Cardiol. 2022 Aug;169:1-9. doi: 10.1016/j.yjmcc.2022.04.019. Epub 2022 Apr 28.
Vascular function is critical for the maintenance of body's homeostasis and is tightly regulated by complex interactions among the vessel wall, hemodynamics, neuro-endocrine factors and metabolic alteration. A variety of cardiovascular risks instigate pro-inflammatory and oxidative responses to impair vascular function, leading to pathological vascular remodeling. Peroxisome proliferator-activated receptor-δ (PPAR-δ) is a ligand-activated nuclear receptor and transcription factor that regulates cell growth and differentiation, metabolism and wound healing. Being expressed in vascular endothelial cells, smooth muscle cells and monocytes, PPAR-δ has pleotropic effects in vascular biology and pathology. In this review, we discussed recent advances regarding the functional roles of PPAR-δ as a critical regulator of vascular homeostasis and as a potential target for the intervention of cardiovascular diseases.
血管功能对于维持身体内环境的稳定至关重要，它受到血管壁、血液动力学、神经内分泌因素和代谢改变之间复杂相互作用的严格调节。各种心血管风险引发促炎和氧化反应，损害血管功能，导致病理性血管重塑。过氧化物酶体增殖物激活受体-δ（PPAR-δ）是一种配体激活的核受体和转录因子，可调节细胞生长和分化、代谢和伤口愈合。PPAR-δ在血管内皮细胞、平滑肌细胞和单核细胞中表达，在血管生物学和病理学中具有多种作用。在这篇综述中，我们讨论了 PPAR-δ作为血管内稳态关键调节因子和心血管疾病干预潜在靶点的功能作用的最新进展。
