Zhang Min, He Shujie
Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2023 Mar 21;14:1169566. doi: 10.3389/fphar.2023.1169566. eCollection 2023.
Peroxisome proliferator-activated receptors (PPARs) are essential nuclear hormone receptors regulating metabolic processes, and they participate in the initiation and progression processes of tumors. Gastrointestinal (GI) cancer is a prevalent malignancy worldwide that originates from the tissues of the gastrointestinal tract and is characterized by severe symptoms and poor prognosis. Numerous published studies have investigated the critical role of PPARs in esophageal, gastric, and colorectal cancers. Here, we summarize and review the current literature to understand the role of PPARs in the pathogenesis of GI cancers and to provide a systematic reference for the subsequent investigation and development of efficient therapies targeting PPARs and their pathways.
过氧化物酶体增殖物激活受体（PPARs）是调节代谢过程的重要核激素受体，它们参与肿瘤的发生和发展过程。胃肠道（GI）癌是一种在全球范围内普遍存在的恶性肿瘤，起源于胃肠道组织，其特征是症状严重且预后不良。大量已发表的研究探讨了PPARs在食管癌、胃癌和结直肠癌中的关键作用。在此，我们总结并回顾当前的文献，以了解PPARs在胃肠道癌发病机制中的作用，并为后续针对PPARs及其信号通路的高效治疗方法的研究和开发提供系统的参考。
