Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Trends Genet. 2022 Aug;38(8):793-796. doi: 10.1016/j.tig.2022.04.001. Epub 2022 Apr 28.
Proper function of structure-specific nucleases is key for faithful Okazaki fragment maturation (OFM) process completion. Deregulation of such nucleases leads to aberrant OFM and causes a spectrum of mutations, some of which may confer survival outcomes under specific stresses and serve as attractive targets for therapeutic intervention in human cancers.
结构特异性核酸酶的正常功能对于忠实完成 Okazaki 片段成熟（OFM）过程至关重要。这些核酸酶的失调会导致异常的 OFM，并导致一系列突变，其中一些突变可能在特定应激下赋予生存结果，并成为人类癌症治疗干预的有吸引力的靶点。
