Cheng Wenbing, Huang Yanbing, Gao Haijun, Bold Bolor, Zhang Ting, Yang Dengfeng
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.
Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Nanning, Guangxi, China.
Handb Exp Pharmacol. 2025;287:325-393. doi: 10.1007/164_2024_712.
Parasitic diseases including malaria, leishmaniasis, and trypanosomiasis have received significant attention due to their severe health implications, especially in developing countries. Marine natural products from a vast and diverse range of marine organisms such as sponges, corals, molluscs, and algae have been found to produce unique bioactive compounds that exhibit promising potent properties, including antiparasitic, anti-Plasmodial, anti-Leishmanial, and anti-Trypanosomal activities, providing hope for the development of effective treatments. Furthermore, various techniques and methodologies have been used to investigate the mechanisms of these antiparasitic compounds. Continued efforts in the discovery and development of marine natural products hold significant promise for the future of novel treatments against parasitic diseases.
包括疟疾、利什曼病和锥虫病在内的寄生虫病因其对健康的严重影响而受到了极大关注，尤其是在发展中国家。人们发现，来自海绵、珊瑚、软体动物和藻类等种类繁多的海洋生物的海洋天然产物能产生独特的生物活性化合物，这些化合物具有包括抗寄生虫、抗疟原虫、抗利什曼原虫和抗锥虫活性在内的有前景的强效特性，为开发有效治疗方法带来了希望。此外，人们还采用了各种技术和方法来研究这些抗寄生虫化合物的作用机制。在海洋天然产物的发现和开发方面持续做出的努力，为未来新型抗寄生虫病治疗方法带来了巨大希望。
