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临床研究结局的统计学考虑:常见数据类型和方法学综述。

Statistical considerations for outcomes in clinical research: A review of common data types and methodology.

机构信息

Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN 38152, USA.

出版信息

Exp Biol Med (Maywood). 2022 May;247(9):734-742. doi: 10.1177/15353702221085710. Epub 2022 May 1.

Abstract

With the increasing number and variety of clinical trials and observational data analyses, producers and consumers of clinical research must have a working knowledge of an array of statistical methods. Our goal with this body of work is to highlight common types of data and analyses in clinical research. We provide a brief, yet comprehensive overview of common data types in clinical research and appropriate statistical methods for analyses. These include continuous data, binary data, count data, multinomial data, and time-to-event data. We include references for further studies and real-world examples of the application of these methods. In summary, we review common continuous and discrete data, summary statistics for said data, common hypothesis tests and appropriate statistical tests, and underlying assumption for the statistical tests. This information is summarized in tabular format, for additional accessibility.

摘要

随着临床试验和观察性数据分析的数量和种类不断增加,临床研究的生产者和使用者必须对一系列统计方法有一定的了解。我们的目标是强调临床研究中常见的数据类型和分析方法。我们简要而全面地介绍了临床研究中常见的数据类型以及分析这些数据的适当统计方法。这些方法包括连续数据、二项数据、计数数据、多项数据和生存数据。我们还提供了进一步研究的参考文献和这些方法应用的实际示例。总之,我们回顾了常见的连续数据和离散数据、这些数据的汇总统计信息、常见的假设检验和适当的统计检验以及统计检验的基本假设。这些信息以表格形式总结,以提高可访问性。

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