Lee Sang Yoon, Lim Hyung San, Lee Na Eun, Cho Sung Oh
Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea
RSC Adv. 2020 Jan 2;10(1):356-361. doi: 10.1039/c9ra09752j. eCollection 2019 Dec 20.
We present a novel approach to preparing non-toxic sunscreen active ingredients by electron irradiation of poly(methyl methacrylate) (PMMA) and polystyrene (PS) nanoparticles (NPs). Electron irradiation modifies the molecular structure of the polymers, generating conjugated aliphatic carbon-carbon double bonds in PMMA and conjugated aromatic rings in PS. The conjugation length increases as the electron fluence increases, leading to hyperchromic and bathochromic shifts in the UV-vis absorption spectra of the irradiated polymer NPs. Consequently, the irradiated polymer NPs become capable of UV absorption and the UV-absorbing properties are improved with increasing electron fluence. The UV-screening performance of the electron-irradiated polymer NPs are found to be superior to those of commercially available sunscreen ingredients. In addition, cytotoxicity and phototoxicity test results show that the irradiated polymer NPs exhibit excellent biocompatibility.
我们提出了一种通过对聚甲基丙烯酸甲酯（PMMA）和聚苯乙烯（PS）纳米颗粒（NPs）进行电子辐照来制备无毒防晒活性成分的新方法。电子辐照改变了聚合物的分子结构，在PMMA中产生共轭脂肪族碳 - 碳双键，在PS中产生共轭芳环。随着电子注量的增加，共轭长度增加，导致辐照后的聚合物纳米颗粒的紫外 - 可见吸收光谱发生增色和红移。因此，辐照后的聚合物纳米颗粒变得能够吸收紫外线，并且随着电子注量的增加，紫外线吸收性能得到改善。发现电子辐照的聚合物纳米颗粒的紫外线屏蔽性能优于市售防晒成分。此外，细胞毒性和光毒性测试结果表明，辐照后的聚合物纳米颗粒具有优异的生物相容性。
