Poulson Benjamin Gabriel, Szczepski Kacper, Lachowicz Joanna Izabela, Jaremko Lukasz, Emwas Abdul-Hamid, Jaremko Mariusz
Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900 Saudi Arabia
Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria 09042 Monserrato Italy.
RSC Adv. 2019 Dec 24;10(1):215-227. doi: 10.1039/c9ra09350h. eCollection 2019 Dec 20.
The process of aggregation of proteins and peptides is dependent on the concentration of proteins, and the rate of aggregation can be altered by the presence of metal ions, but this dependence is not always a straightforward relationship. In general, aggregation does not occur under normal physiological conditions, yet it can be induced in the presence of certain metal ions. However, the extent of the influence of metal ion interactions on protein aggregation has not yet been fully comprehended. A consensus has thus been difficult to reach because the acceleration/inhibition of the aggregation of proteins in the presence of metal ions depends on several factors such as pH and the concentration of the aggregated proteins involved as well as metal concentration level of metal ions. Metal ions, like Cu, Zn, Pb may either accelerate or inhibit aggregation simply because the experimental conditions affect the behavior of biomolecules. It is clear that understanding the relationship between metal ion concentration and protein aggregation will prove useful for future scientific applications. This review focuses on the dependence of the aggregation of selected important biomolecules (peptides and proteins) on metal ion concentrations. We review proteins that are prone to aggregation, the result of which can cause serious neurodegenerative disorders. Furthering our understanding of the relationship between metal ion concentration and protein aggregation will prove useful for future scientific applications, such as finding therapies for neurodegenerative diseases.
蛋白质和肽的聚集过程取决于蛋白质的浓度，金属离子的存在可改变聚集速率，但这种依赖性并不总是直接的关系。一般来说，在正常生理条件下不会发生聚集，但在某些金属离子存在时可诱导聚集。然而，金属离子相互作用对蛋白质聚集的影响程度尚未完全了解。因此，由于在金属离子存在下蛋白质聚集的加速/抑制取决于几个因素，如pH值、所涉及的聚集蛋白质的浓度以及金属离子的金属浓度水平，所以很难达成共识。像铜、锌、铅等金属离子可能会加速或抑制聚集，仅仅是因为实验条件会影响生物分子的行为。显然，了解金属离子浓度与蛋白质聚集之间的关系将对未来的科学应用有用。本综述重点关注选定的重要生物分子（肽和蛋白质）的聚集对金属离子浓度的依赖性。我们综述了易于聚集的蛋白质，其聚集结果可能导致严重的神经退行性疾病。进一步了解金属离子浓度与蛋白质聚集之间的关系将对未来的科学应用有用，例如寻找神经退行性疾病的治疗方法。
