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如何应用转化模型探究心脏毒性机制。

How to Apply Translational Models to Probe Mechanisms of Cardiotoxicity.

作者信息

Livingston Carissa E, Ky Bonnie, Margulies Kenneth B

机构信息

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

出版信息

JACC CardioOncol. 2022 Mar 15;4(1):130-135. doi: 10.1016/j.jaccao.2022.01.097. eCollection 2022 Mar.

DOI:10.1016/j.jaccao.2022.01.097
PMID:35492822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9040120/
Abstract

• Treatment-related cardiovascular disease is a leading cause of morbidity and mortality in cancer survivors. • For investigators, it is crucial that in vitro models are well-matched to the toxicity studied. • From simple to complex, we describe how in vitro models are used to model cardiotoxicity. • Integrating these models will provide opportunities to address growing challenges in cardio-oncology.

摘要

• 与治疗相关的心血管疾病是癌症幸存者发病和死亡的主要原因。

• 对于研究人员而言，体外模型与所研究的毒性良好匹配至关重要。

• 从简单到复杂，我们描述了体外模型如何用于模拟心脏毒性。

• 整合这些模型将为应对心脏肿瘤学中日益增长的挑战提供机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f70d/9040120/4f9d4d10a05f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f70d/9040120/4f9d4d10a05f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f70d/9040120/4f9d4d10a05f/fx1.jpg

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Circ Res. 2021 Jun 25;129(1):e21-e34. doi: 10.1161/RES.0000000000000473. Epub 2021 May 3.
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Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity.人诱导多能干细胞-心脏内皮肿瘤芯片用于评估抗癌疗效和心脏毒性。
Tissue Eng Part C Methods. 2020 Jan;26(1):44-55. doi: 10.1089/ten.TEC.2019.0248. Epub 2020 Jan 3.
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Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association.
利用培养的犬心肌切片模型研究阿霉素诱导的自噬流。
PLoS One. 2023 Mar 16;18(3):e0282859. doi: 10.1371/journal.pone.0282859. eCollection 2023.
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Cardiotoxicity and pro-inflammatory effects of the immune checkpoint inhibitor Pembrolizumab associated to Trastuzumab.免疫检查点抑制剂 Pembrolizumab 联合曲妥珠单抗的心脏毒性和促炎作用。
Int J Cardiol. 2019 Oct 1;292:171-179. doi: 10.1016/j.ijcard.2019.05.028. Epub 2019 May 17.
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