FGF21 调节酒精摄入：酒精使用障碍治疗新希望？
FGF21 regulates alcohol intake: New hopes on the rise for alcohol use disorder treatment?
机构信息
National Institutes of Health, Baltimore, MD 21224, USA.
出版信息
Cell Rep Med. 2022 Mar 15;3(3):100578. doi: 10.1016/j.xcrm.2022.100578.
Abstract
FGF21 is a liver-derived hormone primarily involved in glucose/lipid metabolism. A recent study by Flippo and colleagues demonstrates that administration of FGF21 or an FGF21 analog suppresses alcohol consumption in rodents and non-human primates, likely through an amygdalo-striatal circuit.
摘要
成纤维细胞生长因子 21（FGF21）是一种主要在肝脏中产生的激素，参与调节葡萄糖/脂质代谢。最近，Flippo 等人的研究表明，FGF21 或其类似物的给药可以抑制啮齿动物和非人灵长类动物的酒精摄入，可能通过杏仁核-纹状体回路实现。
Zotero 插件