Wang Tammy, Tyler Ryan E, Ilaka Oyenike, Cooper Diane, Farokhnia Mehdi, Leggio Lorenzo
Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA.
Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, USA.
iScience. 2024 Jun 25;27(7):110389. doi: 10.1016/j.isci.2024.110389. eCollection 2024 Jul 19.
Existing literature indicates that communication between the central nervous system and the peripheral nervous system is disrupted by substance use disorders (SUDs), including alcohol use disorder (AUD). Fibroblast growth factor 21 (FGF21), a liver-brain axis hormone governing energy homeostasis, has been shown to modulate alcohol intake/preference and other substances. To further elucidate the relationship between FGF21, alcohol use, and other substance use, we conducted a scoping review to explore the association between FGF21 and SUDs. Increases in FGF21 reduce alcohol consumption while suppressing FGF21 increases alcohol consumption, demonstrating an inverse relationship. Alcohol elevates FGF21 levels primarily via the liver, subsequently promoting neuronal signals to curb alcohol intake. FGF21 activation engages molecular pathways that defend against alcohol-induced fat accumulation, oxidative stress, and inflammation. Considering the bidirectional association between FGF21 and alcohol, further studies on the FGF21 system as a potential pharmacotherapy for AUD and alcohol-associated liver disease are warranted.
现有文献表明，物质使用障碍（SUDs），包括酒精使用障碍（AUD），会破坏中枢神经系统与外周神经系统之间的通信。成纤维细胞生长因子21（FGF21）是一种调节能量稳态的肝脑轴激素，已被证明可调节酒精摄入量/偏好及其他物质。为了进一步阐明FGF21、酒精使用和其他物质使用之间的关系，我们进行了一项范围综述，以探讨FGF21与物质使用障碍之间的关联。FGF21水平升高会减少酒精消费，而抑制FGF21则会增加酒精消费，呈现出一种负相关关系。酒精主要通过肝脏升高FGF21水平，随后促进神经元信号以抑制酒精摄入。FGF21激活涉及抵御酒精诱导的脂肪堆积、氧化应激和炎症的分子途径。鉴于FGF21与酒精之间的双向关联，有必要对FGF21系统作为酒精使用障碍和酒精相关肝病的潜在药物治疗进行进一步研究。
