Bobrowska Anna, Murton Molly, Seedat Farah, Visintin Cristina, Mackie Anne, Steele Robert, Marshall John
Costello Medical, 50/60 Station Road, Cambridge CB1 2JH, UK.
UK National Screening Committee, Southside, 39 Victoria Street, London SW1H 0EU, UK.
Lancet Reg Health Eur. 2022 Apr 14;16:100353. doi: 10.1016/j.lanepe.2022.100353. eCollection 2022 May.
A recent report on screening in the UK proposed that the responsibility for recommendations on population and targeted screening programmes should be held by one new integrated advisory body. There is no wide international consensus on the definition of targeted screening. Our review identified and compared the defining components of screening terms: targeted, population, selective, and cascade screening, and case finding. Definitions of targeted screening and population screening were clearly demarcated by the eligible population; targeted and selective screening were found to be conceptually interchangeable; cascade screening, whilst conceptually similar to targeted screening across several components, was only used within the context of genetic diseases. There was little consensus between different definitions of case finding. These comparisons contributed to an updated definition of targeted screening. Considerable overlap between definition components across terms implies that a broad range of disease areas may fall into the remit of the new advisory body.
英国最近一份关于筛查的报告提议，应由一个新的综合咨询机构负责就人群和目标性筛查计划提出建议。对于目标性筛查的定义，国际上尚未达成广泛共识。我们的综述确定并比较了筛查术语的定义要素：目标性、人群、选择性、级联筛查和病例发现。目标性筛查和人群筛查的定义通过 eligible population 明确区分；目标性筛查和选择性筛查在概念上被发现是可互换的；级联筛查虽然在几个要素上与目标性筛查概念相似，但仅在遗传疾病的背景下使用。病例发现的不同定义之间几乎没有共识。这些比较促成了目标性筛查的更新定义。各术语定义要素之间存在相当大的重叠，这意味着广泛的疾病领域可能属于新咨询机构的职责范围。
