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用于快速检测过氧亚硝酸盐和生物硫醇的香豆素基荧光探针。

Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols.

作者信息

Wu Luling, Tian Xue, Groleau Robin R, Wang Jie, Han Hai-Hao, Reeksting Shaun B, Sedgwick Adam C, He Xiao-Peng, Bull Steven D, James Tony D

机构信息

Department of Chemistry, University of Bath Bath BA2 7AY UK

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology 130 Meilong Rd. Shanghai 200237 China.

出版信息

RSC Adv. 2020 Apr 3;10(23):13496-13499. doi: 10.1039/d0ra02234a. eCollection 2020 Apr 1.

Abstract

A coumarin-based novel 'AND' logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.

摘要

一种基于香豆素的新型“与”逻辑荧光探针ROS-AHC已被开发用于同时检测过氧亚硝酸根(ONOO)和生物硫醇。结果表明,单独加入谷胱甘肽(GSH)或过氧亚硝酸根(ONOO)分析物时,ROS-AHC仅表现出非常小的荧光响应。然而,同时暴露于这两种分析物会导致荧光显著增强。

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