Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China.
Cardiothoracic Surgery Department, Affiliated Hospital of Nantong University, Nantong, China.
Front Immunol. 2022 Apr 13;13:837665. doi: 10.3389/fimmu.2022.837665. eCollection 2022.
Transient Receptor Potential (TRP) channel is a kind of channel protein widely distributed in peripheral and central nervous system. They can be regulated by natural aromatic substances and serve as a therapeutic target for many diseases. However, the role and function of the TRP family genes in tumours remain unclear.
Gene alterations (mutation, copy number, methylation), expression, clinical features, and prognostic value of the TRP family genes were evaluated in pan-cancer using data from The Cancer Genome Atlas and Genotype-Tissue Expression databases. TRP score was calculated by the ssGSEA function of the R package "GSVA". The association of TRP score and the tumour microenvironment (TME), especially the tumour immune microenvironment (TIME), along with immunotherapy response were explored in-depth.
TRP family genes were involved in tumour progression and highly associated with poor prognosis in a variety of cancers. TRP score was positively associated with malignant pathways in pan-cancer, such as IL6-JAK-STAT3 signalling, interferon-gamma response, and inflammatory response. All pathways were closely associated with TIME. Elevated TRP score also correlated with multiple immune-related characteristics of the TIME in pan-cancer. Moreover, the TRP score was a predictive biomarker for immune checkpoint inhibitor (ICI) treatments in patients with tumours.
TRP family genes play a key role in pan-cancer and are closely associated with TME. Patients with high TRP scores have excellent immune-activated TIME and immunotherapy sensitivity. Therefore, the TRP score could be a potential biomarker for patients with tumours treated with ICI.
瞬时受体电位 (TRP) 通道是一种广泛分布于外周和中枢神经系统的通道蛋白。它们可以被天然芳香物质调节，作为许多疾病的治疗靶点。然而，TRP 家族基因在肿瘤中的作用和功能尚不清楚。
使用来自癌症基因组图谱和基因型组织表达数据库的数据，评估 TRP 家族基因在泛癌中的基因改变（突变、拷贝数、甲基化）、表达、临床特征和预后价值。通过 R 包“GSVA”的 ssGSEA 功能计算 TRP 评分。深入探讨 TRP 评分与肿瘤微环境（TME），特别是肿瘤免疫微环境（TIME）的关系，以及与免疫治疗反应的关系。
TRP 家族基因参与肿瘤的进展，并与多种癌症的不良预后高度相关。TRP 评分与泛癌中的恶性途径呈正相关，如 IL6-JAK-STAT3 信号通路、干扰素-γ反应和炎症反应。所有途径都与 TIME 密切相关。升高的 TRP 评分还与泛癌中 TIME 的多个免疫相关特征相关。此外，TRP 评分是预测肿瘤患者免疫检查点抑制剂 (ICI) 治疗效果的生物标志物。
TRP 家族基因在泛癌中发挥关键作用，与 TME 密切相关。TRP 评分高的患者具有出色的免疫激活 TIME 和免疫治疗敏感性。因此，TRP 评分可能是接受 ICI 治疗的肿瘤患者的潜在生物标志物。
