Mesbahi Tarek, Zaine Hind, Mahazou Abdou Ismaël, Chekrine Tarik, Sahraoui Souha, Karkouri Mehdi, Lakhdar Abdelhakim
Neurosurgery Department of the IBN ROCHD University Hospital Center, Casablanca, Morocco.
Department of Radiotherapy and Oncology of the IBN ROCHD University Hospital Center, Casablanca, Morocco.
Front Oncol. 2022 Apr 13;12:760011. doi: 10.3389/fonc.2022.760011. eCollection 2022.
Glioblastoma multiforme (GBM) is a high-grade glioma that may be a rare complication of radiotherapy. We report a case of a patient who was treated for medulloblastoma (MB) of the posterior fossa at the age of 27 years. Twenty-nine years later, at the age of 56 years, he presented with a double-location tumor: supratentorial and in the posterior fossa. Imaging features of the supratentorial location were very suggestive of a meningioma. We operated on the posterior fossa location, which revealed a glioblastoma. Histologically, the tumor cells exhibited characteristics of both GBM and rhabdoid tumor cells. Literature reports of cases of GBM following MB at the same place are very rare, and presenting rhabdoid characteristics is even rarer. This is the first case of MB and GBM at ages 27 and 56 years, respectively. The double-location supratentorial probable meningioma and GBM of the posterior fossa 32 years after MB is the only case reported in the literature. What to do in this case remains a topic of debate, and there are no clear recommendations in the literature.
多形性胶质母细胞瘤（GBM）是一种高级别胶质瘤，可能是放射治疗的罕见并发症。我们报告一例患者，该患者27岁时接受了后颅窝髓母细胞瘤（MB）的治疗。29年后，56岁时，他出现了双部位肿瘤：幕上和后颅窝。幕上部位的影像学特征非常提示为脑膜瘤。我们对后颅窝部位进行了手术，结果发现是胶质母细胞瘤。组织学上，肿瘤细胞表现出GBM和横纹肌样肿瘤细胞的特征。文献中关于MB后同一部位发生GBM的病例报道非常罕见，而呈现横纹肌样特征的情况更为罕见。这是首例分别在27岁和56岁时发生MB和GBM的病例。MB后32年出现幕上可能为脑膜瘤和后颅窝GBM的双部位情况是文献中报道的唯一病例。该病例的处理方法仍是一个有争议的话题，文献中也没有明确的建议。
