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光触发含脂质体二氢卟吩e6的支链淀粉杂化纳米颗粒释放货物 膜通透性。

Photo-triggered cargo release from liposome chlorin e6-bearing pullulan hybrid nanoparticles membrane permeabilization.

作者信息

Kawasaki Riku, Ohdake Reo, Eto Takuro, Yamana Keita, Nakaya Toshimi, Ishida Takenori, Kuroda Akio, Ikeda Atsushi

机构信息

Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University 1-4-1 Kagamiyama Higashi Hiroshima 739-8527 Japan

Digital Monozukuri (Manufacturing) Education and Research Center, Hiroshima University 3-10-32 Kagamiyama Higashi-Hiroshima 739-0046 Japan.

出版信息

RSC Adv. 2021 Nov 12;11(58):36564-36568. doi: 10.1039/d1ra07807k. eCollection 2021 Nov 10.

Abstract

A liposome chlorin e6-bearing pullulan nanogel hybrid was prepared as a light-triggered payload release platform. The current system enabled manipulation of the release profile of model drugs encapsulated by liposomes. Gelatin hydrogels that comprised hybrid nanoparticles could successfully control the delivery of cargo molecules to human mesenchymal stem cells with light stimuli without injury to the cells.

摘要

制备了一种负载氯in e6的支链淀粉纳米凝胶脂质体杂化物作为光触发的药物释放平台。当前系统能够操控脂质体包裹的模型药物的释放曲线。包含杂化纳米颗粒的明胶水凝胶能够通过光刺激成功控制货物分子向人间充质干细胞的递送,且不会对细胞造成损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbc8/9043425/77893cd8487b/d1ra07807k-f1.jpg

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