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腐植酸作为一种高效且可重复使用的催化剂，用于在水中一锅法三组分绿色合成5-取代-1-四唑。

Humic acid as an efficient and reusable catalyst for one pot three-component green synthesis of 5-substituted 1-tetrazoles in water.

作者信息

Wang Hongshe, Wang Yichun, Han Yinfeng, Zhao Weixing, Wang Xiaomei

机构信息

College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences Baoji 721013 China

College of Pharmacy, Shaanxi University of Chinese Medicine Xianyang 712046 China.

出版信息

RSC Adv. 2020 Jan 3;10(2):784-789. doi: 10.1039/c9ra08523h. eCollection 2020 Jan 2.

DOI:10.1039/c9ra08523h
PMID:35494449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9047532/
Abstract

Humic acid is a non toxic, inexpensive, easily available high-molecular weight polymer. A simple and facile one pot three-component synthesis of 5-substituted 1-tetrazoles from aldehydes, hydroxyamine hydrochloride and sodium azide using humic acid as an efficient catalyst in water is described. The method reported has several advantages such as high to excellent yields, easy work-up, mild reaction conditions, use of water as a green solvent, and a commercially available, nontoxic and reusable catalyst.

摘要

腐殖酸是一种无毒、廉价且易于获得的高分子量聚合物。本文描述了一种简单便捷的一锅三组分合成方法，该方法以腐殖酸为高效催化剂，在水中由醛、盐酸羟胺和叠氮化钠合成5-取代-1-四唑。所报道的方法具有多个优点，如产率高至优异、后处理简便、反应条件温和、使用水作为绿色溶剂以及采用市售、无毒且可重复使用的催化剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eaa/9047532/5da85eba028c/c9ra08523h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eaa/9047532/f4db3bba262c/c9ra08523h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eaa/9047532/5da85eba028c/c9ra08523h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eaa/9047532/f4db3bba262c/c9ra08523h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0eaa/9047532/5da85eba028c/c9ra08523h-s2.jpg

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