• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一名因阿托伐他汀导致横纹肌溶解继发急性肾衰竭的患者,需短期肾脏替代治疗的罕见病例报告 。

A Rare Presentation of Acute Renal Failure Secondary to Rhabdomyolysis in a Patient Due to Atorvastatin Requiring Short-Term Renal Replacement Therapy.

作者信息

Khan Zahid, Ibekwe Mildred, Abumedian Mohammed, Yousif Yousif, Mlawa Gideon

机构信息

Cardiology, Royal Free Hospital, London, GBR.

Internal Medicine, Barking, Havering and Redbridge University Hospitals National Health Service (NHS) Trust, London, GBR.

出版信息

Cureus. 2022 Mar 26;14(3):e23511. doi: 10.7759/cureus.23511. eCollection 2022 Mar.

DOI:10.7759/cureus.23511
PMID:35494968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9037051/
Abstract

Renal failure secondary to rhabdomyolysis due to statins is quite rare. We present a case of a 57-year-old patient who developed acute renal failure due to rhabdomyolysis secondary to atorvastatin. Interestingly, this patient had a similar presentation 27 years ago requiring dialysis only once resulting in complete resolution of symptoms. He presented to the hospital generally feeling unwell and then developed generalized body ache. He had an extremely elevated creatinine kinase level of 116,000 and it went up to 145,000. His urine dip was negative for nitrites and was positive for blood and protein. He was commenced on intravenous fluids. He also had a computerized tomographic scan of the kidneys, ureters, and bladder, which showed some fat stranding around both kidneys likely inflammatory in origin. His creatinine level continue to rise despite intravenous fluids and was acidotic on blood gases. He also tested positive for COVID-19 on day 7 of admission and eventually needed dialysis. His renal functions improved to baseline post dialysis and kidney functions returned to normal. His autoimmune screen was negative and his renal functions remained normal on a follow-up visit.

摘要

他汀类药物引起横纹肌溶解继发的肾衰竭相当罕见。我们报告一例57岁患者,因阿托伐他汀继发横纹肌溶解而发生急性肾衰竭。有趣的是,该患者27年前有过类似表现,仅需透析一次,症状就完全缓解。他因全身不适入院,随后出现全身疼痛。他的肌酸激酶水平极高,达116,000,后来升至145,000。他的尿液试纸检测亚硝酸盐为阴性,血液和蛋白质为阳性。他开始接受静脉补液治疗。他还进行了肾脏、输尿管和膀胱的计算机断层扫描,显示双肾周围有一些脂肪条索,可能起源于炎症。尽管进行了静脉补液,他的肌酐水平仍持续升高,血气分析显示酸中毒。入院第7天他的新冠病毒检测呈阳性,最终需要透析。透析后他的肾功能恢复到基线水平,肾功能恢复正常。他的自身免疫筛查为阴性,随访时肾功能仍保持正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0138/9037051/587284b5219e/cureus-0014-00000023511-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0138/9037051/0b6eabcdd3b3/cureus-0014-00000023511-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0138/9037051/587284b5219e/cureus-0014-00000023511-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0138/9037051/0b6eabcdd3b3/cureus-0014-00000023511-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0138/9037051/587284b5219e/cureus-0014-00000023511-i02.jpg

相似文献

1
A Rare Presentation of Acute Renal Failure Secondary to Rhabdomyolysis in a Patient Due to Atorvastatin Requiring Short-Term Renal Replacement Therapy.一名因阿托伐他汀导致横纹肌溶解继发急性肾衰竭的患者,需短期肾脏替代治疗的罕见病例报告 。
Cureus. 2022 Mar 26;14(3):e23511. doi: 10.7759/cureus.23511. eCollection 2022 Mar.
2
Extremely elevated creatine kinase associated with rhabdomyolysis-induced acute kidney injury in a patient with Huntington's disease: a case report.亨廷顿病患者横纹肌溶解症致急性肾损伤患者肌酸激酶极度升高:病例报告。
J Med Case Rep. 2023 Jul 10;17(1):287. doi: 10.1186/s13256-023-04018-5.
3
Delayed presentation of severe rhabdomyolysis leading to acute kidney injury following atorvastatin-gemfibrozil combination therapy: a case report.阿托伐他汀与吉非贝齐联合治疗后出现严重横纹肌溶解症并导致急性肾损伤的延迟表现:一例病例报告
J Med Case Rep. 2018 May 22;12(1):143. doi: 10.1186/s13256-018-1685-0.
4
COVID-19 causing rhabdomyolysis requiring hemodialysis in a young adult.新型冠状病毒肺炎导致一名年轻成年人发生横纹肌溶解症,需要进行血液透析。
Proc (Bayl Univ Med Cent). 2022 Mar 22;35(4):510-511. doi: 10.1080/08998280.2022.2051787. eCollection 2022.
5
[Acute rhabdomyolysis: a case report and literature review].[急性横纹肌溶解症:一例病例报告及文献综述]
Acta Med Croatica. 2008 Jul;62(3):317-22.
6
Rhabdomyolysis in a patient treated with colchicine and atorvastatin.一名接受秋水仙碱和阿托伐他汀治疗的患者发生横纹肌溶解症。
Ann Pharmacother. 2006 Jul-Aug;40(7-8):1466-9. doi: 10.1345/aph.1H064. Epub 2006 Jun 13.
7
A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial.一项评价阿司匹林、阿托伐他汀和尼可地尔三联疗法在 SARS-CoV-2 感染住院患者中的疗效和安全性的随机、开放标签试验:一项随机对照试验研究方案的结构化总结。
Trials. 2021 Jul 15;22(1):451. doi: 10.1186/s13063-021-05361-y.
8
A patient with severe rhabdomyolysis and high levels of creatinine kinase had renal functions fully recovered after haemodialysis: a case report.一名患有严重横纹肌溶解症且肌酸激酶水平较高的患者在血液透析后肾功能完全恢复:病例报告
J Int Med Res. 2020 Apr;48(4):300060519888105. doi: 10.1177/0300060519888105. Epub 2019 Dec 25.
9
Statin Induced Rhabdomyolysis with Non Oliguric Renal Failure: A Rare Presentation.他汀类药物所致非少尿型肾衰竭横纹肌溶解症:一种罕见表现
J Clin Diagn Res. 2017 Mar;11(3):FD01-FD02. doi: 10.7860/JCDR/2017/24491.9359. Epub 2017 Mar 1.
10
Pravastatin-induced rhabdomyolysis and purpura fulminans in a patient with chronic renal failure.普伐他汀诱发的慢性肾衰竭患者横纹肌溶解症和暴发性紫癜
Int J Surg Case Rep. 2015;8C:84-7. doi: 10.1016/j.ijscr.2015.01.042. Epub 2015 Jan 28.

引用本文的文献

1
A Rare Case of Statin-Induced Rhabdomyolysis With Severe Acute Kidney Injury After a Decade of Therapy.他汀类药物治疗十年后发生罕见的他汀诱导横纹肌溶解症并伴有严重急性肾损伤病例
Cureus. 2024 Nov 3;16(11):e72913. doi: 10.7759/cureus.72913. eCollection 2024 Nov.

本文引用的文献

1
Statin-Induced Rhabdomyolysis, Acute Kidney Injury, and Hepatitis Leading to Death.他汀类药物诱导的横纹肌溶解症、急性肾损伤和肝炎导致死亡。
Am J Case Rep. 2019 May 18;20:709-712. doi: 10.12659/AJCR.914707.
2
Delayed presentation of severe rhabdomyolysis leading to acute kidney injury following atorvastatin-gemfibrozil combination therapy: a case report.阿托伐他汀与吉非贝齐联合治疗后出现严重横纹肌溶解症并导致急性肾损伤的延迟表现:一例病例报告
J Med Case Rep. 2018 May 22;12(1):143. doi: 10.1186/s13256-018-1685-0.
3
Statin-induced rhabdomyolysis in patient with renal failure and underlying undiagnosed hypothyroidism.
他汀类药物诱导的横纹肌溶解症,发生于一名患有肾衰竭及潜在未确诊甲状腺功能减退症的患者。
Indian J Crit Care Med. 2016 May;20(5):305-7. doi: 10.4103/0972-5229.182210.
4
Physiological approach to assessment of acid-base disturbances.酸碱平衡紊乱评估的生理学方法。
N Engl J Med. 2015 Jan 8;372(2):193-4. doi: 10.1056/NEJMc1413880.
5
The controversies of statin therapy: weighing the evidence.他汀类药物治疗的争议:权衡证据。
J Am Coll Cardiol. 2012 Sep 4;60(10):875-81. doi: 10.1016/j.jacc.2012.07.007. Epub 2012 Aug 15.
6
Mannitol increases renal blood flow and maintains filtration fraction and oxygenation in postoperative acute kidney injury: a prospective interventional study.甘露醇可增加肾血流量,并维持术后急性肾损伤患者的滤过分数和氧合:一项前瞻性干预研究。
Crit Care. 2012 Aug 17;16(4):R159. doi: 10.1186/cc11480.
7
Statin-associated rhabdomyolysis: is there a dose-response relationship?他汀类药物相关性横纹肌溶解症:是否存在剂量反应关系?
Can J Cardiol. 2011 Mar-Apr;27(2):146-51. doi: 10.1016/j.cjca.2010.12.024.
8
Rhabdomyolysis and acute kidney injury.横纹肌溶解症与急性肾损伤。
N Engl J Med. 2009 Jul 2;361(1):62-72. doi: 10.1056/NEJMra0801327.
9
Statin induced myopathy.他汀类药物引起的肌病
BMJ. 2008 Nov 6;337:a2286. doi: 10.1136/bmj.a2286.
10
Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study.高脂血症患者高剂量他汀类药物治疗的轻至中度肌肉症状——PRIMO研究
Cardiovasc Drugs Ther. 2005 Dec;19(6):403-14. doi: 10.1007/s10557-005-5686-z.