Munro J M, van der Walt J D, Munro C S, Chalmers J A, Cox E L
Hum Pathol. 1987 Apr;18(4):375-80. doi: 10.1016/s0046-8177(87)80168-5.
Recent studies have shown both macrophages and lymphocytes in very early intimal lesions of experimental aortic atherosclerosis. The authors obtained fresh samples of human aortic wall, which had been removed in the course of aortocoronary bypass graft surgery. Intimal fatty streaks were identified macroscopically and six were studied immunohistochemically. The fatty streaks contained foam cells that were virtually all labeled by antibodies directed against members of the mononuclear phagocyte series (RFD-2 and RFD-7). Macrophages demonstrated acid phosphatase activity and marked expression of HLA-DR, suggesting activation. Other monoclonal antibodies (UCHT-1, OKT-4, and RFT-8) identified T lymphocytes, of both helper and suppressor phenotypes, within the fatty streaks. T lymphocytes of suppressor phenotype appeared to predominate over helper cells. B lymphocytes were not detected. The presence of activated macrophages and T lymphocytes in the fatty streaks indicates that components of a cell-mediated immune response are present. Such an immune process may be important in the pathogenesis of human atherosclerosis.
最近的研究表明，在实验性主动脉粥样硬化的极早期内膜病变中存在巨噬细胞和淋巴细胞。作者获取了在主动脉冠状动脉搭桥手术过程中切除的人主动脉壁新鲜样本。肉眼识别出内膜脂肪条纹，并对其中6个进行了免疫组织化学研究。脂肪条纹中含有泡沫细胞，这些泡沫细胞几乎都被针对单核吞噬细胞系列成员的抗体（RFD - 2和RFD - 7）标记。巨噬细胞表现出酸性磷酸酶活性和HLA - DR的显著表达，提示激活。其他单克隆抗体（UCHT - 1、OKT - 4和RFT - 8）在脂肪条纹中识别出具有辅助和抑制表型的T淋巴细胞。抑制表型的T淋巴细胞似乎比辅助细胞占优势。未检测到B淋巴细胞。脂肪条纹中活化的巨噬细胞和T淋巴细胞的存在表明存在细胞介导免疫反应的成分。这样的免疫过程可能在人类动脉粥样硬化的发病机制中起重要作用。
