Ramshaw A L, Parums D V
University of Oxford, Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, UK.
Histopathology. 1990 Dec;17(6):543-52. doi: 10.1111/j.1365-2559.1990.tb00794.x.
During repair of 12 atherosclerotic abdominal aortic aneurysms, fresh samples of aneurysm wall were obtained. Histology confirmed the presence of advanced atherosclerosis associated with medial thinning and a variable aortic adventitial chronic inflammatory cell infiltrate. Monoclonal antibodies were used to identify the inflammatory cells throughout the aortic wall. The majority of lymphocytes in the aortic adventitia were B-cells. B-cells were not present in atheromatous plaques. T-cells, predominantly T-helper cells, were found in atheromatous plaques and in aortic adventitia. The majority of lymphocytes and macrophages in aortic adventitia and most vascular endothelial cells were HLA-DR positive. Ki-67 staining was found in B-cells and T-helper cells, indicating that these cells were proliferating. Occasional lymphocytes were BerH2 positive, indicating that some lymphocytes were activated. These findings suggest that chronic periaortitis is an active, immunologically mediated, local complication of advanced human atherosclerosis.
在修复12例动脉粥样硬化性腹主动脉瘤的过程中，获取了动脉瘤壁的新鲜样本。组织学检查证实存在与中膜变薄以及主动脉外膜慢性炎症细胞浸润程度各异相关的晚期动脉粥样硬化。使用单克隆抗体来识别整个主动脉壁中的炎症细胞。主动脉外膜中的大多数淋巴细胞是B细胞。动脉粥样硬化斑块中不存在B细胞。在动脉粥样硬化斑块和主动脉外膜中发现了T细胞，主要是辅助性T细胞。主动脉外膜中的大多数淋巴细胞和巨噬细胞以及大多数血管内皮细胞HLA - DR呈阳性。在B细胞和辅助性T细胞中发现了Ki - 67染色，表明这些细胞在增殖。偶尔有淋巴细胞BerH2呈阳性，表明一些淋巴细胞被激活。这些发现提示慢性主动脉周炎是晚期人类动脉粥样硬化的一种活跃的、免疫介导的局部并发症。
