Chen Yongli, Xian Yiwen, Carrier Andrew J, Youden Brian, Servos Mark, Cui Shufen, Luan Tiangang, Lin Sujing, Zhang Xu
Postdoctoral Innovation Practice Base, Shenzhen Polytechnic Shenzhen 518055 China.
State Key Laboratory Biocontrol, School of Marine Sciences, Sun Yat-sen University Guangzhou 510275 China.
RSC Adv. 2020 Apr 20;10(26):15541-15546. doi: 10.1039/d0ra01382j. eCollection 2020 Apr 16.
Polymeric microneedles (MNs) are attractive transdermal drug delivery systems because of their efficient drug delivery and minimal invasiveness. Master template fabrication is the most time-consuming and costly step in producing polymeric MNs using a micromoulding approach. Herein, this issue is addressed by modifying tattoo needle cartridges by adjusting the volume of a PDMS spacer, thus streamlining polymeric MN fabrication and significantly reducing its manufacturing cost. Using the fabricated master template, dissolvable polymeric MN systems containing poly(vinyl pyrrolidone) (PVP) and poly(vinyl alcohol) (PVA) were developed. This MN system exhibits several advantages, including controllable MN length, uniform distribution of each needle, and controllable drug release profiles. Overall, polymeric MN fabrication using this method is inexpensive, simple, and yields controllable and effective transdermal drug delivery.
聚合物微针（MNs）因其高效的药物递送和最小的侵入性而成为有吸引力的经皮给药系统。在使用微模塑方法生产聚合物微针时，母模板制造是最耗时且成本最高的步骤。在此，通过调整聚二甲基硅氧烷（PDMS）间隔物的体积来修改纹身针筒，从而解决了这个问题，简化了聚合物微针的制造并显著降低了其制造成本。使用制造的母模板，开发了包含聚乙烯吡咯烷酮（PVP）和聚乙烯醇（PVA）的可溶解聚合物微针系统。该微针系统具有几个优点，包括可控的微针长度、每根针的均匀分布以及可控的药物释放曲线。总体而言，使用这种方法制造聚合物微针成本低廉、操作简单，并且能够实现可控且有效的经皮给药。
