Ali Fatima Ramzan, Shoaib Muhammad Harris, Ali Syed Abid, Yousuf Rabia Ismail, Ahmed Farrukh Rafiq, Siddiqui Fahad, Sarfaraz Sana, Raja Rameez
Department of Pharmaceutics, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, 75270, Pakistan.
H.E.J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Ther Deliv. 2024;15(8):605-617. doi: 10.1080/20415990.2024.2377065. Epub 2024 Jul 29.
Insulin therapy require self-administration of subcutaneous injection leading to painful and inconvenient drug therapy. The aim is to fabricate nanoemulsion (NE) based insulin loaded microneedles with improved bioavailability and patient compliance. Different ratios of polyvinyl alcohol and polyvinylpyrrolidone as polymers were prepared through micro-molding technique for microneedles. Characterization of were performed using scanning electron microscope, differential scanning calorimetry, Fourier-transform infrared spectroscopy and circular dichroism. Mechanical strength, hygroscopicity and pain perception of these microneedles were also evaluated. release, permeation and PK/PD study of NE-based microneedles were conducted. NE-based microneedles of insulin have improved bioavailability and quick response. Microneedles loaded with insulin can be effectively delivered insulin transdermally to treat diabetes with increased convenience and patient compliance.
胰岛素治疗需要自行皮下注射，这导致药物治疗既痛苦又不方便。目的是制备基于纳米乳剂（NE）的载胰岛素微针，以提高生物利用度和患者顺应性。通过微成型技术制备了不同比例的聚乙烯醇和聚乙烯吡咯烷酮作为聚合物的微针。使用扫描电子显微镜、差示扫描量热法、傅里叶变换红外光谱和圆二色性进行表征。还评估了这些微针的机械强度、吸湿性和疼痛感知。进行了基于NE的微针的释放、渗透和药代动力学/药效学研究。基于NE的胰岛素微针具有提高的生物利用度和快速反应。载有胰岛素的微针可以有效地经皮递送胰岛素以治疗糖尿病，增加了便利性和患者顺应性。
