Qu Botao, Li Xiaoyan, Zhang Xiaomin, Li Weihua, Zhang Ruiping
School of Basic Medical Sciences, Shanxi Medical University, Imaging College of Shanxi Medical University, Imaging Department of the Affiliated Da Yi Hospital of Shanxi Medical University Taiyuan 030001 Shanxi China
Department of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen 518035 Guangdong China.
RSC Adv. 2020 Apr 17;10(26):15221-15227. doi: 10.1039/d0ra01638a. eCollection 2020 Apr 16.
Antimony selenide (SbSe) as a simple, low toxicity, low-cost p-type semiconductor material with broad absorbance ranging from the UV to the NIR region has many potential applications in photovoltaic, thermoelectric, and phase-change memory devices. Owing to these excellent properties, SbSe nanorods were firstly synthesized with triphenylantimony and dibenzyldiselenide under solvothermal conditions. In order to enhance the biocompatibility of the SbSe nanorods, polyvinylpyrrolidone (PVP) was coated onto the surface of the SbSe nanorods to form PVP-coated SbSe nanorods. The cell viability of PVP-coated SbSe nanorods toward Hep-2 cells was assessed for 24 h using a Cell Counting Kit-8 (CCK-8) assay. The results showed that Hep-2 cells treated with PVP-coated SbSe nanorods were alive at a concentration as high as 100 μg mL in the absence of NIR irradiation. assessment confirmed that PVP-coated SbSe nanorods exhibited excellent photoacoustic imaging and PTT performance, which yielded complete ablation of tumors after laser irradiation (808 nm or 980 nm) in the NIR-I bio-window.
硒化锑（SbSe）作为一种简单、低毒、低成本的p型半导体材料，具有从紫外到近红外区域的广泛吸光度，在光伏、热电和相变存储器件中有许多潜在应用。由于这些优异的性能，首先在溶剂热条件下用三苯基锑和二苄基二硒合成了SbSe纳米棒。为了提高SbSe纳米棒的生物相容性，将聚乙烯吡咯烷酮（PVP）包覆在SbSe纳米棒表面，形成PVP包覆的SbSe纳米棒。使用细胞计数试剂盒-8（CCK-8）测定法评估PVP包覆的SbSe纳米棒对Hep-2细胞的细胞活力24小时。结果表明，在没有近红外辐射的情况下，用PVP包覆的SbSe纳米棒处理的Hep-2细胞在高达100μg/mL的浓度下仍存活。评估证实，PVP包覆的SbSe纳米棒表现出优异的光声成像和光热治疗性能，在近红外-I生物窗口中激光照射（808nm或980nm）后可完全消融肿瘤。
