School of Food and Biological Engineering, School of Chemistry and Chemical Engineering , Hefei University of Technology , Hefei 230009 , P. R. China.
State Key Laboratory of Advanced Welding and Joining , Harbin Institute of Technology , Harbin 150001 , P. R. China.
ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26664-26673. doi: 10.1021/acsami.9b08320. Epub 2019 Jul 19.
The ever-growing global crisis of multidrug-resistant bacteria has triggered a tumult of activity in the design and development of antibacterial formulations. Here, atomically thin antimony selenide nanosheets (SbSe NSs), a minimal-toxic and low-cost semiconductor material, were explored as a high-performance two-dimensional (2D) antibacterial nanoagent via a liquid exfoliation strategy integrating cryo-pretreatment and polyvinyl pyrrolidone (PVP)-assisted exfoliation. When cultured with bacteria, the obtained PVP-capped SbSe NSs exhibited intrinsic long-term antibacterial capability, probably due to the reactive oxygen species generation and sharp edge-induced membrane cutting during physical contact between bacteria and nanosheets. Upon near-infrared laser irradiation, SbSe NSs achieved short-time hyperthermia sterilization because of strong optical absorption and high photothermal conversion efficiency. By virtue of the synergistic effects of these two broad-spectrum antibacterial mechanisms, SbSe NSs exhibited high-efficiency inhibition of conventional Gram-negative , Gram-positive methicillin-resistant , and wild bacteria from a natural water pool. Particularly, these three categories of bacteria were completely eradicated after being treated with SbSe NSs (300 μM) plus laser irradiation for only 5 min. In vivo wound healing experiment further demonstrated the high-performance antibacterial effect. In addition, SbSe NSs depicted excellent biocompatibility due to the biocompatible element constitute and bioinert PVP modification. This work enlightened that atomically thin SbSe NSs hold great promise as a broad-spectrum 2D antibacterial nanoagent for various pathogenic bacterial infections.
不断增长的全球多药耐药菌危机引发了抗菌制剂设计和开发的热潮。在这里，原子级薄的硒化锑纳米片（SbSe NSs）作为一种低毒、低成本的半导体材料，通过结合低温预处理和聚乙烯吡咯烷酮（PVP）辅助剥离的液体剥离策略，被探索为一种高性能二维（2D）抗菌纳米剂。当与细菌共培养时，所获得的 PVP 封端的 SbSe NSs 表现出内在的长期抗菌能力，这可能是由于细菌与纳米片物理接触时活性氧的产生和尖锐边缘诱导的膜切割。在近红外激光照射下，SbSe NSs 由于强烈的光吸收和高光热转换效率而实现了短时间的高热杀菌。由于这两种广谱抗菌机制的协同作用，SbSe NSs 对传统的革兰氏阴性、革兰氏阳性耐甲氧西林和来自天然水池的野生细菌表现出高效抑制作用。特别是，这三类细菌在用 SbSe NSs（300 μM）加激光照射处理仅 5 分钟后就被完全根除。体内伤口愈合实验进一步证明了其高效的抗菌作用。此外，由于组成元素的生物相容性和生物惰性 PVP 修饰，SbSe NSs 表现出优异的生物相容性。这项工作启发我们，原子级薄的 SbSe NSs 有望成为一种广谱的 2D 抗菌纳米剂，用于各种致病性细菌感染。
