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基于二氮丙啶的甜味剂衍生物在阐明甜味受体化学感受机制方面的最新进展。

Recent progress in the use of diaziridine-based sweetener derivatives to elucidate the chemoreception mechanism of the sweet taste receptor.

作者信息

Hashimoto Makoto, Nakagita Tomoya, Misaka Takumi

机构信息

Division of Applied Science, Graduate School of Agriculture, Hokkaido University Kita 9, Nishi 9, Kita-ku Sapporo 060-8589 Japan

Department of Agricultural Chemistry, School of Agriculture, Meiji University Kawasaki Kanagawa 214-8571 Japan.

出版信息

RSC Adv. 2021 Oct 1;11(51):32236-32247. doi: 10.1039/d1ra04831g. eCollection 2021 Sep 27.

DOI:10.1039/d1ra04831g
PMID:35495529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9041848/
Abstract

All sweeteners are recognized by the sweet taste receptor (T1R2-T1R3). The elucidation of the chemoreception mechanism of receptor-ligand interactions is an attractive topic for researchers. Molecular biology and computational biology techniques can reveal the proposed mechanisms for this topic. Other approaches, including chemical biology (bioorganic chemistry), have helped to identify mechanisms on the basis of molecular structure. In this mini-review, we have summarized the recent progress in the synthesis of sweetener derivatives, which includes the use of photoaffinity labeling of diazirine-based derivatives to elucidate the chemoreception of sweeteners.

摘要

所有甜味剂都能被甜味受体（T1R2 - T1R3）识别。阐明受体 - 配体相互作用的化学感受机制是研究人员感兴趣的课题。分子生物学和计算生物学技术能够揭示该课题的推测机制。其他方法，包括化学生物学（生物有机化学），有助于基于分子结构确定机制。在本综述中，我们总结了甜味剂衍生物合成方面的最新进展，其中包括使用基于重氮丙啶的衍生物进行光亲和标记以阐明甜味剂的化学感受。

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