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Leucomethylene blue probe detects a broad spectrum of reactive oxygen and nitrogen species.

作者信息

Cremer Christopher, Merkes Jean Michél, Bub Christina L, Rommel Dirk, Patureau Frederic W, Banala Srinivas

机构信息

Institute of Organic Chemistry, RWTH Aachen University Landoltweg 1 Aachen Germany.

Institute for Experimental Molecular Imaging, University Clinic, RWTH Aachen Forckenbeckstrasse 55 Germany

出版信息

RSC Adv. 2021 Sep 29;11(51):32295-32299. doi: 10.1039/d1ra06498c. eCollection 2021 Sep 27.

DOI:10.1039/d1ra06498c
PMID:35495535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9041740/
Abstract

Reactive oxygen and nitrogen species (ROS, RNS) are ubiquitous in biology with a variety of physiological and pathological functions. Here we describe a broad spectrum ROS/RNS detecting fluorogenic probe with red fluorescence emission and up to 100-fold gain. Hence these modified probes are useful for non-invasive quantification of ROS/RNS.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/d8863c1bc2ff/d1ra06498c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/8b33412d2c02/d1ra06498c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/2776c6a2e156/d1ra06498c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/35cec25d5ecb/d1ra06498c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/91a3d1b12b5f/d1ra06498c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/d8863c1bc2ff/d1ra06498c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/8b33412d2c02/d1ra06498c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/2776c6a2e156/d1ra06498c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/35cec25d5ecb/d1ra06498c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/91a3d1b12b5f/d1ra06498c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9590/9041740/d8863c1bc2ff/d1ra06498c-f4.jpg

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ACS Sens. 2021 Dec 24;6(12):4379-4388. doi: 10.1021/acssensors.1c01674. Epub 2021 Dec 13.
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Advances in Imaging Reactive Oxygen Species.活性氧物种成像的新进展
J Nucl Med. 2021 Apr;62(4):457-461. doi: 10.2967/jnumed.120.245415. Epub 2020 Dec 31.
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Methylene blue mediated antimicrobial photodynamic therapy in clinical human studies: The state of the art.亚甲蓝介导的抗菌光动力疗法在人体临床研究中的现状
Photodiagnosis Photodyn Ther. 2020 Sep;31:101828. doi: 10.1016/j.pdpdt.2020.101828. Epub 2020 May 28.
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Photodynamic therapy treatment of superficial fungal infections: A systematic review.光动力疗法治疗浅表真菌感染：一项系统综述。
Photodiagnosis Photodyn Ther. 2020 Sep;31:101774. doi: 10.1016/j.pdpdt.2020.101774. Epub 2020 Apr 25.
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Methylene blue as a far-red light-mediated photocleavable multifunctional ligand.亚甲蓝作为一种远红光介导的光解多功能配体。
Chem Commun (Camb). 2020 Feb 6;56(11):1673-1676. doi: 10.1039/c9cc08916k.
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Acc Chem Res. 2019 Sep 17;52(9):2582-2597. doi: 10.1021/acs.accounts.9b00302. Epub 2019 Aug 28.
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Photodiagnosis Photodyn Ther. 2019 Dec;28:146-152. doi: 10.1016/j.pdpdt.2019.08.005. Epub 2019 Aug 5.
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ACS Sens. 2019 Aug 23;4(8):2001-2008. doi: 10.1021/acssensors.9b00224. Epub 2019 Jul 18.
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