2,4-二羟基苯甲醛和2,4-二羟基苯乙酮的区域选择性烷基化反应
Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones.
作者信息
Frank Aziza, Hamidi Negar, Xue Fengtian
机构信息
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States.
出版信息
Tetrahedron Lett. 2022 Apr 13;95. doi: 10.1016/j.tetlet.2022.153755. Epub 2022 Mar 23.
Abstract
We report a cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzyaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated products in acetonitrile at 80 °C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope.
摘要
我们报道了一种碳酸铯介导的2,4-二羟基苯甲醛和2,4-二羟基苯乙酮的烷基化反应，该反应在80℃的乙腈中进行，生成4-烷基化产物，具有优异的区域选择性、高达95%的分离产率以及广泛的底物范围。
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