Frank Aziza, Hamidi Negar, Xue Fengtian
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States.
Tetrahedron Lett. 2022 Apr 13;95. doi: 10.1016/j.tetlet.2022.153755. Epub 2022 Mar 23.
We report a cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzyaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated products in acetonitrile at 80 °C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope.
我们报道了一种碳酸铯介导的2,4-二羟基苯甲醛和2,4-二羟基苯乙酮的烷基化反应，该反应在80℃的乙腈中进行，生成4-烷基化产物，具有优异的区域选择性、高达95%的分离产率以及广泛的底物范围。
