Xu Lei, Ho Chi-Tang, Liu Yanan, Wu Zufang, Zhang Xin
Department of Food Science and Engineering, Ningbo University, Ningbo, China.
Department of Food Science, Rutgers University, New Brunswick, NJ, United States.
Front Nutr. 2022 Apr 14;9:899842. doi: 10.3389/fnut.2022.899842. eCollection 2022.
Coronavirus disease 2019 (COVID-19) disrupts the intestinal micro-ecological balance, and patients often develop the intestinal disease. The gut is the largest immune organ in the human body; intestinal microbes can affect the immune function of the lungs through the gut-lung axis. It has been reported that tea polyphenols (TPs) have antiviral and prebiotic activity. In this review, we discussed TPs reduced lung-related diseases through gut-lung axis by inhibiting dysbiosis. In addition, we also highlighted the preventive and therapeutic effects of TPs on COVID-19 complications, further demonstrating the importance of research on TPs for the prevention and treatment of COVID-19 in humans. Based on this understanding, we recommend using TPs to regulate the gut microbiota to prevent or alleviate COVID-19 through the gut-lung axis.
2019冠状病毒病（COVID-19）会破坏肠道微生态平衡，患者常出现肠道疾病。肠道是人体最大的免疫器官；肠道微生物可通过肠-肺轴影响肺部的免疫功能。据报道，茶多酚（TPs）具有抗病毒和益生元活性。在本综述中，我们讨论了茶多酚通过抑制肠道菌群失调，经肠-肺轴减轻肺部相关疾病。此外，我们还强调了茶多酚对COVID-19并发症的预防和治疗作用，进一步证明了研究茶多酚对人类预防和治疗COVID-19的重要性。基于这一认识，我们建议使用茶多酚调节肠道微生物群，通过肠-肺轴预防或减轻COVID-19。
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