Lima Marcelo T, Finelli Fernanda G, de Oliveira Alline V B, Kartnaller Vinicius, Cajaiba João F, Leão Raquel A C, de Souza Rodrigo O M A
Biocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro 21941909 Brazil
Instituto de Pesquisas de Produtos Naturais, Federal University of Rio de Janeiro 21941909 Brazil.
RSC Adv. 2020 Jan 16;10(5):2490-2494. doi: 10.1039/c9ra09119j. eCollection 2020 Jan 14.
Dimethyl fumarate (DMF) is a methyl ester of fumaric acid and has recently gained attention due to its use as a pro-drug in different pharmaceutical preparations, besides the low price of the final molecule and no active patents being available for the synthesis of DMF, the prices of multiple sclerosis treatment are still high. In our continuous effort for the development of process intensification strategies towards the synthesis of active pharmaceutical ingredients, here we present our work on a cascade methodology for dimethyl fumarate synthesis in short reaction times and quantitative yields.
富马酸二甲酯（DMF）是富马酸的甲酯，由于其在不同药物制剂中用作前药而受到关注。此外，最终分子价格低廉且合成DMF没有有效的专利，多发性硬化症治疗的价格仍然很高。在我们持续致力于开发活性药物成分合成的过程强化策略的过程中，在此展示我们关于在短反应时间内以定量产率合成富马酸二甲酯的级联方法的工作。
