用于与穿透深度无关的光动力疗法的化学发光有机纳米光敏剂。
Chemiluminescent organic nanophotosensitizer for a penetration depth independent photodynamic therapy.
作者信息
Lu Xiaomei, Song Xingwen, Wang Qi, Hu Wenbo, Shi Wei, Tang Yufu, Wu Zizi, Fan Quli, Huang Wei
机构信息
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), Nanjing Tech University (Nanjing Tech) Nanjing 211816 China
Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NUPT) Nanjing 210023 China
出版信息
RSC Adv. 2020 Mar 24;10(20):11861-11864. doi: 10.1039/d0ra01477j. eCollection 2020 Mar 19.
Photodynamic therapy initiated by external photoexcitation is a clinically-approved therapeutic paradigm, but its practical application has been severely hindered by the shallow penetration of light. Here, we describe a penetration-independent PDT modality using a chemiluminescent organic nanophotosensitizer, which is activated by hydrogen peroxide instead of external photoexcitation.
由外部光激发引发的光动力疗法是一种临床认可的治疗模式，但其实际应用因光的浅穿透性而受到严重阻碍。在此，我们描述了一种使用化学发光有机纳米光敏剂的与穿透无关的光动力疗法模式，该光敏剂由过氧化氢而非外部光激发激活。
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