Hu Wenbo, He Tingchao, Jiang Rongcui, Yin Jun, Li Lin, Lu Xiaomei, Zhao Hui, Zhang Lei, Huang Ling, Sun Handong, Huang Wei, Fan Quli
Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
Chem Commun (Camb). 2017 Feb 4;53(10):1680-1683. doi: 10.1039/c6cc09473b. Epub 2017 Jan 19.
Herein, we experimentally and theoretically demonstrate an unprecedentedly enhanced two-photon absorption in a small organic molecule by a simple introduction of an inner salt-shaped structure. Moreover, such an inner salt-shaped small molecule also exhibits superior singlet oxygen quantum yield and fascinating structure-inherent mitochondrial-targeting ability for highly efficient two-photon photodynamic therapy via a mitochondrial apoptosis pathway.
在此，我们通过简单引入内盐形结构，在实验和理论上证明了一种小分子有机化合物中前所未有的双光子吸收增强。此外，这种内盐形小分子还表现出优异的单线态氧量子产率，以及通过线粒体凋亡途径进行高效双光子光动力治疗的迷人的结构固有线粒体靶向能力。
