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F DCFPyL PSMA 亲和性活检证实的皮下毛细血管瘤在生化复发前列腺癌背景下可模拟恶性肿瘤。

F DCFPyL PSMA avid biopsy proven subcutaneous capillary haemangioma as a malignancy mimic in the setting of biochemical recurrent prostate carcinoma.

作者信息

Dhillon Manvinder, Singh Dalveer

机构信息

School of Medicine, University of Queensland, Herston, QLD 4006 Australia.

Qscan Radiology Clinics, Brisbane, QLD 7000 Australia.

出版信息

Radiol Case Rep. 2022 Apr 19;17(6):2211-2214. doi: 10.1016/j.radcr.2022.03.082. eCollection 2022 Jun.

DOI:10.1016/j.radcr.2022.03.082
PMID:35496754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9048037/
Abstract

We present a case of a 65-year-old male with a biopsy proven subcutaneous capillary haemangioma identified on imaging for evaluation of further metastatic spread of prostatic carcinoma due to a rise in his prostate-specific antigen biochemistry. He was receiving salvage radiation therapy for his known isolated nodal disease, four years after prostatectomy. An intensely avid prostate-specific membrane antigen positron emission tomography-computed tomography lesion in the left paramedian back at the level of L1 was noted on his scan. A core biopsy revealed a dermal haemangioma with no evidence of metastatic prostatic carcinoma. To our knowledge, only one other incidental case of prostate-specific membrane antigen avid subcutaneous capillary haemangioma has been described in the literature. Whilst uncommon, incidental findings of prostate-specific membrane antigen PET avid dermal lesions are pathognomonic for haemangiomas and can be treated as "no touch" lesions with watchful observation.

摘要

我们报告一例65岁男性病例,该患者因前列腺特异性抗原生化指标升高,为评估前列腺癌进一步转移扩散而进行影像学检查时,经活检证实存在皮下毛细血管瘤。他在前列腺切除术后四年,因已知的孤立性淋巴结疾病接受挽救性放射治疗。在他的扫描中发现,在L1水平左旁正中背部有一个前列腺特异性膜抗原正电子发射断层扫描-计算机断层扫描高度摄取的病变。一次穿刺活检显示为真皮血管瘤,没有前列腺癌转移的证据。据我们所知,文献中仅描述过另一例偶然发现的前列腺特异性膜抗原摄取的皮下毛细血管瘤病例。虽然不常见,但偶然发现的前列腺特异性膜抗原PET摄取的皮肤病变是血管瘤的特征性表现,可作为“不干预”病变进行密切观察。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf2/9048037/1e9e77dce83c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf2/9048037/5d821e0fc46b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf2/9048037/1a78c7316db8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf2/9048037/1e9e77dce83c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf2/9048037/5d821e0fc46b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf2/9048037/1a78c7316db8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcf2/9048037/1e9e77dce83c/gr3.jpg

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本文引用的文献

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Nonprostatic diseases on PSMA PET imaging: a spectrum of benign and malignant findings.PSMA PET 成像中的非前列腺疾病:一系列良性和恶性表现。
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Unexpected significant findings non-related to prostate cancer identified using combined prostate-specific membrane antigen positron emission tomography/CT and diagnostic CT scan in primary staging for prostate cancer.
在前列腺癌的初始分期中,使用前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描(PSMA PET/CT)与诊断性CT扫描相结合的方法,发现了与前列腺癌无关的意外重大发现。
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Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions.犬血管肉瘤细胞过表达前列腺特异性膜抗原为检测血液腔积液中疾病负担提供了分子检测的机会。
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