Boulet Salix, Le Corre Laure, Odagiu Livia, Labrecque Nathalie
Maisonneuve-Rosemont Hospital Research Center, Montréal, QC H1T 2M4, Canada.
Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Curr Res Immunol. 2022 Feb 22;3:23-36. doi: 10.1016/j.crimmu.2022.02.001. eCollection 2022.
The myeloid cellular compartment comprises monocytes, dendritic cells (DCs), macrophages and granulocytes. As diverse as this group of cells may be, they are all an important part of the innate immune system and are therefore linked by the necessity to be acutely sensitive to their environment and to rapidly and appropriately respond to any changes that may occur. The nuclear orphan receptors NR4A1, NR4A2 and NR4A3 are encoded by immediate early genes as their expression is rapidly induced in response to various signals. It is perhaps because of this characteristic that this family of transcription factors has many known roles in myeloid cells. In this review, we will regroup and discuss the diverse roles NR4As have in different myeloid cell subsets, including in differentiation, migration, activation, and metabolism. We will also highlight the importance these molecules have in the development of myeloid leukemia.
髓样细胞区室包括单核细胞、树突状细胞（DC）、巨噬细胞和粒细胞。尽管这群细胞各不相同，但它们都是固有免疫系统的重要组成部分，因此因需要对其环境高度敏感并对可能发生的任何变化迅速做出适当反应而联系在一起。核孤儿受体NR4A1、NR4A2和NR4A3由即刻早期基因编码，因为它们的表达会响应各种信号而迅速被诱导。也许正是由于这一特性，这个转录因子家族在髓样细胞中具有许多已知作用。在本综述中，我们将重新整理并讨论NR4A在不同髓样细胞亚群中的多种作用，包括在分化、迁移、激活和代谢方面的作用。我们还将强调这些分子在髓样白血病发生发展中的重要性。
